Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Ultrasound Med Biol. 2019 Oct;45(10):2658-2665. doi: 10.1016/j.ultrasmedbio.2019.06.413. Epub 2019 Jul 19.
We compared texture parameters of serial cranial ultrasound (cUS) images of periventricular leukomalacia (PVL) and normal periventricular echogenicity (PVE) in very preterm infants and evaluated the early predictive values of texture analysis (TA) for PVL. Ten individuals with PVL and 10 control individuals with PVE assessed with an initial cUS within 1 wk of birth and follow-up cUS at 2-3 and 4-6 wk of life were included. TA was performed on the region of interest of PVE at the parieto-occipital area on serial cUS. Opposite changes in variance were obtained between the first two cUS sessions in both groups (p = 0.017 in PVL and p = 0.005 in PVE). The variance-to-mean ratio (VMR) between the second and first cUS sessions differed (p = 0.016) and reliably stratified the groups (area under the receiver operating characteristic curve: 0.820, 95% confidence interval: 0.587-1.000, sensitivity: 100%, specificity: 60%). TA of serial cUS helps to predict PVL within 3 wk of life.
我们比较了早产儿脑室周围白质软化症（PVL）和正常脑室周围回声增强（PVE）的连续头颅超声（cUS）图像的纹理参数，并评估了纹理分析（TA）对 PVL 的早期预测价值。10 名 PVL 患者和 10 名 PVE 对照者在出生后 1 周内进行了首次 cUS 评估，并在 2-3 周和 4-6 周龄时进行了随访 cUS。在连续 cUS 的顶枕区 PVE 感兴趣区域进行 TA。两组在前两个 cUS 检查中均获得方差的相反变化（PVL 中 p=0.017，PVE 中 p=0.005）。第二和第一个 cUS 检查之间的方差-均值比（VMR）不同（p=0.016），并可靠地区分了两组（接受者操作特征曲线下面积：0.820，95%置信区间：0.587-1.000，灵敏度：100%，特异性：60%）。连续 cUS 的 TA 有助于在 3 周内预测 PVL。
