Tokunaga T, Akagawa K S
Department of Cellular Immunology, National Institute of Health, Tokyo, Japan.
Tokai J Exp Clin Med. 1986;11 Suppl:89-96.
While mouse peritoneal macrophages respond well to lipopolysaccharide, lung macrophages were neither activated for tumor cell cytotoxicity nor killed directly by it. The unresponsiveness of lung macrophages was ascribed to lack of expression of lipopolysaccharide-binding sites on the cell surface. It was found that in vitro treatment of lung macrophages with interferon-gamma or in vivo sensitization of them with viable BCG restored the response by expression of the lipopolysaccharide binding sites. The modes of action of interferon-gamma and BCG in expressing the binding sites on mouse lung macrophages are discussed.
虽然小鼠腹腔巨噬细胞对脂多糖反应良好，但肺巨噬细胞既不被激活产生肿瘤细胞细胞毒性，也不会被其直接杀死。肺巨噬细胞无反应性归因于细胞表面缺乏脂多糖结合位点的表达。研究发现，用γ干扰素体外处理肺巨噬细胞或用活卡介苗体内致敏肺巨噬细胞，可通过脂多糖结合位点的表达恢复其反应性。本文讨论了γ干扰素和卡介苗在小鼠肺巨噬细胞上表达结合位点的作用方式。
