Beshtawi Ithar M, Qaddomi Jamal, Khuffash Hanady, El-Titi Safa, Ghannam Malak, Otaibi Reema
Optometry Department, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, West Bank, Palestine.
Nursing Department, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, West Bank, Palestine.
J Optom. 2019 Oct-Dec;12(4):248-255. doi: 10.1016/j.optom.2019.03.001. Epub 2019 Jul 19.
To compare the biocompatibility and subjective symptoms of four multipurpose solutions marketed in Palestine with hydrogel contact lenses.
50 habitual soft contact lens wearers were recruited in this interventional crossover study. Subjects were asked to attend the optometry clinic five times. A new pair of hydrogel lenses (Bioxifilcon-B) were fitted each time. This pair was soaked randomly overnight in one of the following four-multipurpose solutions (NEOPLUS, AvizorUnicaSensitive, ReNuMultiPlus and COMPLETERevitaLens) which contain different disinfecting agents (PHMB, Phx, PAPB, and PQ-1+Alexidine, respectively), or non-preserved saline. At each visit, corneal staining, ocular redness and subjective symptoms were assessed.
The percentage of corneal staining increased significantly (P≤0.050) after soaking the lenses with PHMB (86%), PAPB (64%) and Phx (32%) based-solutions. However, a non-significant increase was noticed after the use of PQ-1+Alexidine based solution (30%, P=0.083). Ocular redness evaluation showed a significant increase (P≤0.050) in limbal hyperemia after the use of all solutions, while bulbar redness was significantly increased after the use of biguanide-based solutions (P≤0.050). The subjective assessment analysis showed a non-significant change in comfort, dryness, photophobia and scratchiness (P≥0.050) at 2-h intervention using all solutions, except for the PHMB based solution which showed a significant change in subjective symptoms (P≤0.050).
The combination of Bioxifilcon-B hydrogel contact lenses and solution containing PHMB, PAPB and Phx-disinfectants induced a significant increase in corneal staining after 2h of CL-wear with a higher severity when the PHMB-based solution was used, while the PQ-1+Alexidine-based solution did not. Only the PHMB-based solution triggered a significant change in subjective symptoms which might which suggests that it might be related to the severity of staining rather than the induction of staining.
比较巴勒斯坦市场上销售的四种多功能护理液与水凝胶隐形眼镜的生物相容性和主观症状。
在这项介入性交叉研究中招募了50名习惯性软性隐形眼镜佩戴者。受试者被要求到验光诊所就诊五次。每次都佩戴一副新的水凝胶镜片（Bioxifilcon-B）。这副镜片随机在以下四种多功能护理液（NEOPLUS、AvizorUnicaSensitive、ReNuMultiPlus和COMPLETERevitaLens）中的一种中浸泡过夜，这四种护理液分别含有不同的消毒剂（聚六亚甲基双胍、苯氧乙醇、对氯间二甲苯酚和PQ-1+双氯苯双胍己烷），或无防腐剂的生理盐水。每次就诊时，评估角膜染色、眼部发红情况和主观症状。
用含聚六亚甲基双胍（86%）、对氯间二甲苯酚（64%）和苯氧乙醇（32%）的护理液浸泡镜片后，角膜染色百分比显著增加（P≤0.050）。然而，使用含PQ-1+双氯苯双胍己烷的护理液后染色有非显著性增加（30%，P = 0.083）。眼部发红评估显示，使用所有护理液后角膜缘充血显著增加（P≤0.050），而使用含双胍类护理液后球结膜充血显著增加（P≤0.050）。主观评估分析显示，在2小时干预时，使用所有护理液后舒适度、干燥感、畏光和刺痛感无显著变化（P≥0.050），但含聚六亚甲基双胍的护理液主观症状有显著变化（P≤0.050）。
Bioxifilcon-B水凝胶隐形眼镜与含聚六亚甲基双胍、对氯间二甲苯酚和苯氧乙醇消毒剂的护理液组合，在佩戴隐形眼镜2小时后角膜染色显著增加，使用含聚六亚甲基双胍的护理液时严重程度更高，而含PQ-1+双氯苯双胍己烷的护理液则不会。只有含聚六亚甲基双胍的护理液引发了主观症状的显著变化，这可能表明其与染色严重程度有关，而非染色的诱导有关。
