红色发光二极管受白细胞介素-6影响，促进口腔鳞状细胞癌细胞系的迁移能力。
Red LED Light Is Influenced by IL-6 to Promote the Migration Ability of Oral Squamous Cell Carcinoma Cell Line.
作者信息
Matsuo Kenji, Suzuki Hiroaki, Yatagai Nanae, Enomoto Yui, Kitayama Midori, Shigeoka Manabu, Kimoto Akira, Matsumoto Kosuke, Komori Takahide
机构信息
Department of Oral Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Department of Oral Maxillofacial Surgery, Kakogawa Central City Hospital, Kakogawa, Japan.
出版信息
Kobe J Med Sci. 2019 Jul 10;64(6):E210-E216.
Abstract
AIM
The purpose of this study was to search for the influence of red LED light of oral squamous cell carcinoma cells (OSCC) Material & Methods: HSC-3 was irradiated with red LED light (630 nm/3 J). Proliferative capacity was analyzed using WST-1. Transwell migration assay, real-time PCR, and ELISA method were also used to analyze migratory ability.
CONCLUSIONS
HSC-3 cells irradiated with red LED light showed increased migration ability. Interestingly, we clarified that the expression of Interleukin-6 (IL-6), which promotes the migratory ability of cancer cells, is induced.
摘要
目的
本研究旨在探寻红色发光二极管（LED）光对口腔鳞状细胞癌细胞（OSCC）的影响。
材料与方法
用红色LED光（630纳米/3焦耳）照射HSC-3细胞。使用WST-1分析增殖能力。还采用Transwell迁移试验、实时聚合酶链反应（PCR）和酶联免疫吸附测定（ELISA）法分析迁移能力。
结论
经红色LED光照射的HSC-3细胞迁移能力增强。有趣的是，我们明确发现，促进癌细胞迁移能力的白细胞介素-6（IL-6）的表达被诱导。
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