Dillon Kearsley M, Powell Chadwick R, Matson John B
Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.
Virginia Tech Center for Drug Discovery, Blacksburg, Virginia, 24061, United States.
Synlett. 2019 Mar;30(5):525-531. doi: 10.1055/s-0037-1611693. Epub 2019 Jan 9.
HS, persulfides (R-SSH), and related sulfur species have recently received attention due to the pronounced physiological effects they elicit. Delivering sulfur signaling molecules in a controlled manner presents many challenges, as many available donors have short half-lives, lack water solubility, and exhibit poor trigger specificity. Self-immolative prodrugs provide a unique ability to impart stability to HS precursors and persulfides while allowing for trigger specificity by tuning the functional group installed on the self-immolative linker. This strategy has proven successful in delivering sulfur signaling species under specific conditions and may lead to the further elucidation of persulfide interactions within biological systems, affording effective therapeutics.
硫化氢（HS）、过硫化物（R-SSH）及相关含硫物种因其引发的显著生理效应，近来受到了关注。以可控方式递送硫信号分子存在诸多挑战，因为许多现有的供体半衰期短、缺乏水溶性且触发特异性差。自牺牲前药具有独特的能力，可为HS前体和过硫化物赋予稳定性，同时通过调节安装在自牺牲连接基上的官能团实现触发特异性。这一策略已被证明在特定条件下递送硫信号物质方面是成功的，并且可能会进一步阐明生物系统中的过硫化物相互作用，从而提供有效的治疗方法。
