过硫化物化 HS 信号转导的化学生物学
Chemical Biology of HS Signaling through Persulfidation.
机构信息
Univeristy of Bordeaux, IBGC, UMR 5095 , F-33077 Bordeaux, France.
CNRS, IBGC, UMR 5095 , F-33077 Bordeaux, France.
出版信息
Chem Rev. 2018 Feb 14;118(3):1253-1337. doi: 10.1021/acs.chemrev.7b00205. Epub 2017 Nov 7.
Abstract
Signaling by HS is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of HS. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of HS and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.
摘要
HS 的信号转导被认为是通过过硫化作用发生的，这是半胱氨酸残基（RSH）转化为过硫化物（RSSH）的一种翻译后修饰。过硫化作用为理解 HS 的生理和药理作用提供了一个框架。由于过硫化物的固有不稳定性，它们的化学性质还没有得到充分研究。在这篇综述中，我们讨论了 HS 的生物学相关化学以及其产生和氧化的酶促途径。我们涵盖了过硫化物的化学生物学和检测它们的化学探针。最后，我们讨论了蛋白质过硫化作用在细胞信号通路中的作用。
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