抗雄激素醋酸阿比特龙可提高他汀类药物对去势抵抗性前列腺癌细胞的治疗效果。
Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells.
作者信息
Miller Dannah R, Ingersoll Matthew A, Chou Yu-Wei, Wakefield C Brent, Tu Yaping, Lin Fen-Fen, Chaney William G, Lin Ming-Fong
机构信息
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
BioBank/Tissue Bank, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, China.
出版信息
J Oncol Res Ther. 2017;3(5). Epub 2017 Dec 20.
The treatment of castration-resistant (CR) prostate cancer (PCa) is limited. A sub-population of CR PCa tumors can synthesize androgens for intracrine androgen receptor (AR) activation, thus targeting androgen biosynthesis could be an effective therapeutic option for these patients. We determined that androgen biosynthesis inhibitors simvastatin, atorvastatin, and ketoconazole directly inhibit growth, migration, and colony formation of LNCaP C-81 cells, which exhibit androgen biosynthesis, with simvastatin being the most effective. Importantly, in combination treatments, statins specifically enhanced growth suppression with added effects by anti-androgen abiraterone acetate on the CR PCa cells. Thus, statins can be used in conjunction with abiraterone acetate to enhance anti-androgen therapy for CR PCa.
去势抵抗性（CR）前列腺癌（PCa）的治疗方法有限。CR PCa肿瘤的一个亚群能够合成雄激素以进行内分泌雄激素受体（AR）激活，因此靶向雄激素生物合成可能是这些患者的一种有效治疗选择。我们确定雄激素生物合成抑制剂辛伐他汀、阿托伐他汀和酮康唑直接抑制LNCaP C - 81细胞的生长、迁移和集落形成，这些细胞具有雄激素生物合成能力，其中辛伐他汀最为有效。重要的是，在联合治疗中，他汀类药物通过添加抗雄激素醋酸阿比特龙对CR PCa细胞产生额外作用，特异性地增强了生长抑制效果。因此，他汀类药物可与醋酸阿比特龙联合使用，以增强对CR PCa的抗雄激素治疗。
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