Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark.
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Bipolar Disord. 2019 May;21(3):270-275. doi: 10.1111/bdi.12684. Epub 2018 Jul 26.
The primary aim of this study was to examine whether the mortality of patients with bipolar disorder has increased over the past two decades as compared with the background population.
All patients registered with a bipolar disorder diagnosis in the Danish Psychiatric Research Registry from 1965 until the end of 2014, living in Denmark, alive and below the age of 65 years in the study period from 1995 to 2014 were included. Included patients reaching the age of 65 years during the study period were censored at that time point. Overall standardized mortality ratios (SMRs) were calculated for each calendar year over the study period, and trends in SMR over the study period were examined using linear regression. In addition, the SMRs were stratified according to age groups.
Patients with bipolar disorder had an overall elevated mortality rate relative to the general population with an SMR of 2.8, 95% confidence interval (CI): 2.8-2.9. The highest SMR was found among the youngest (15-29 years: 8.2, 95% CI: 6.7-10.1; 30-34 years: 7.7, 95% CI: 6.4-9.3; 35-39 years: 6.2, 95% CI: 5.4-7.2; 40-44 years: 4.6, 95% CI: 4.1-5.1; 45-49 years: 3.5, 95% CI: 3.3-3.8; 50-54 years: 3.2, 95% CI: 3.0-3.4; 55-59 years: 2.7, 95% CI: 2.6-2.8; and 60-64 years: 2.2, 95% CI: 2.1-2.3). An increase in SMR of 0.03 per year in patients diagnosed with bipolar disorder (P < 0.01) was found.
The mortality gap between patients with bipolar disorder and the general Danish population has widened over the past two decades, which is a cause for concern, although reasons for the increasing mortality gap are unknown.
本研究的主要目的是检查过去二十年来，与普通人群相比，双相情感障碍患者的死亡率是否有所增加。
本研究纳入了 1965 年至 2014 年底期间在丹麦精神病学研究登记处注册的双相情感障碍患者，这些患者生活在丹麦，在 1995 年至 2014 年的研究期间存活且年龄在 65 岁以下。在研究期间达到 65 岁的患者将在该时间点被删失。在整个研究期间，计算了每个日历年度的总体标准化死亡率（SMR），并使用线性回归检查了研究期间 SMR 的趋势。此外，还根据年龄组对 SMR 进行了分层。
与普通人群相比，双相情感障碍患者的总体死亡率偏高，SMR 为 2.8，95%置信区间（CI）为 2.8-2.9。在年龄最小的患者中，SMR 最高，为 15-29 岁：8.2，95%CI：6.7-10.1；30-34 岁：7.7，95%CI：6.4-9.3；35-39 岁：6.2，95%CI：5.4-7.2；40-44 岁：4.6，95%CI：4.1-5.1；45-49 岁：3.5，95%CI：3.3-3.8；50-54 岁：3.2，95%CI：3.0-3.4；55-59 岁：2.7，95%CI：2.6-2.8；60-64 岁：2.2，95%CI：2.1-2.3。发现双相情感障碍患者的 SMR 每年增加 0.03（P < 0.01）。
在过去的二十年中，双相情感障碍患者与丹麦普通人群之间的死亡率差距已经扩大，这令人担忧，尽管导致死亡率差距扩大的原因尚不清楚。
