Finch N C, Stallwood J, Tasker S, Hibbert A
Bristol Veterinary School, University of Bristol, Bristol, BS40 5DU, UK.
Bristol Renal, Bristol Medical School, University of Bristol, Bristol, BS1 3NY, UK.
J Small Anim Pract. 2019 Sep;60(9):523-528. doi: 10.1111/jsap.13057. Epub 2019 Jul 22.
To describe the effect of low-dose (111MBq) radioiodine therapy on thyroid and renal function in hyperthyroid cats over a 12-month follow-up period.
Client-owned hyperthyroid cats underwent low-dose radioiodine therapy and were followed-up for 12 months. Immediately before radioiodine treatment, and at 1, 6 and 12 months afterwards, total thyroxine, thyroid stimulating hormone, serum creatinine and glomerular filtration rate were measured.
Fifteen of the 24 (63%) cats achieved euthyroidism following low-dose radioiodine treatment. The incidence of overt hypothyroidism was six of 24 (25%) cats. Of the six cats developing overt hypothyroidism, three had decreased renal function, with decreased glomerular filtration rate preceding azotaemia in two of these individuals. Transient overt or subclinical hypothyroidism before restoration of euthyroidism was not observed.
Low-dose radioiodine is effective treatment for hyperthyroidism in most cats but overt hypothyroidism may develop in some. Concurrent early decline in renal function may only be detected by measuring glomerular filtration rate rather than serum creatinine in some cats. Monitoring following radioiodine treatment should include total thyroxine and thyroid stimulating hormone and measurement of glomerular filtration rate should be considered in non-azotaemic cats.
描述低剂量（111MBq）放射性碘治疗对甲状腺功能亢进猫甲状腺和肾功能在12个月随访期内的影响。
客户拥有的甲状腺功能亢进猫接受低剂量放射性碘治疗，并随访12个月。在放射性碘治疗前即刻以及治疗后1、6和12个月，测量总甲状腺素、促甲状腺激素、血清肌酐和肾小球滤过率。
24只猫中有15只（63%）在低剂量放射性碘治疗后实现甲状腺功能正常。明显甲状腺功能减退的发生率为24只猫中的6只（25%）。在发生明显甲状腺功能减退的6只猫中，3只肾功能下降，其中2只在氮血症出现之前肾小球滤过率就已降低。在恢复甲状腺功能正常之前未观察到短暂的明显或亚临床甲状腺功能减退。
低剂量放射性碘对大多数猫的甲状腺功能亢进是有效的治疗方法，但在一些猫中可能会发生明显的甲状腺功能减退。在一些猫中，肾功能的早期同时下降可能只能通过测量肾小球滤过率而不是血清肌酐来检测。放射性碘治疗后的监测应包括总甲状腺素和促甲状腺激素，对于无氮血症的猫应考虑测量肾小球滤过率。
