Zhou Zhengxiong, Du Guocheng, Kang Zhen
Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China.
School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China.
Sheng Wu Gong Cheng Xue Bao. 2019 Jul 25;35(7):1222-1233. doi: 10.13345/j.cjb.180527.
Sulfated compounds are widely present in cytoplasm, on cell surface, and in extracellular matrix. These compounds play important roles in cell development, differentiation, immune response, detoxication, and cell signal transduction. 3-Phosphoadenosine-5-phosphosulfate (PAPS) is the universal sulfate group donor for the biosynthesis of sulfated compounds. Up to now, the synthesis of PAPS is still too expensive for industrial applications. This review focuses on the recent progress of PAPS production and summaries the application of PAPS, particularly in the production of glucosinolate, heparin, condroitin sulfate, and oxamniquine production.
硫酸化化合物广泛存在于细胞质、细胞表面和细胞外基质中。这些化合物在细胞发育、分化、免疫反应、解毒和细胞信号转导中发挥着重要作用。3'-磷酸腺苷-5'-磷酸硫酸酯（PAPS）是硫酸化化合物生物合成的通用硫酸基团供体。到目前为止，PAPS的合成对于工业应用来说仍然过于昂贵。本综述重点关注PAPS生产的最新进展，并总结了PAPS的应用，特别是在硫代葡萄糖苷、肝素、硫酸软骨素和奥沙尼喹生产中的应用。
