白细胞介素-6受体（IL-6R）在人胃癌中的表达及其临床意义
Interleukin-6 Receptor (IL-6R) Expression in Human Gastric Carcinoma and its Clinical Significance.
作者信息
Simondurairaj C, Krishnakumar R, Sundaram Sandhya, Venkatraman Ganesh
机构信息
Department of Pathology, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University) , Chennai , India.
Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University) , Chennai , India.
出版信息
Cancer Invest. 2019;37(7):293-298. doi: 10.1080/07357907.2019.1638395. Epub 2019 Jul 22.
The aim of the study is to analyse the expression of Interleukin-6 receptor in different human gastric tissue and to correlate with the clinicopathological features of the patients. Immunohistochemistry was done against the IL-6R antibody and the Q-score was calculated from the staining pattern. Higher Q-scores were observed in tumour cells than the adjacent normal cells which were statistically significant. We also observed a significant correlation between the expressions of IL-6R and the clinicopathological features These findings suggest that IL-6R may represent as a therapeutic target for gastric carcinoma and serve as a prognostic indicator, as well.
本研究的目的是分析白细胞介素-6受体在不同人类胃组织中的表达，并将其与患者的临床病理特征相关联。采用抗IL-6R抗体进行免疫组织化学检测，并根据染色模式计算Q值。肿瘤细胞中的Q值高于相邻正常细胞，具有统计学意义。我们还观察到IL-6R的表达与临床病理特征之间存在显著相关性。这些发现表明，IL-6R可能是胃癌的治疗靶点，也可作为预后指标。
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