Simondurairaj C, Krishnakumar R, Sundaram Sandhya, Venkatraman Ganesh
Department of Pathology, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University) , Chennai , India.
Department of Human Genetics, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University) , Chennai , India.
Cancer Invest. 2019;37(7):293-298. doi: 10.1080/07357907.2019.1638395. Epub 2019 Jul 22.
The aim of the study is to analyse the expression of Interleukin-6 receptor in different human gastric tissue and to correlate with the clinicopathological features of the patients. Immunohistochemistry was done against the IL-6R antibody and the Q-score was calculated from the staining pattern. Higher Q-scores were observed in tumour cells than the adjacent normal cells which were statistically significant. We also observed a significant correlation between the expressions of IL-6R and the clinicopathological features These findings suggest that IL-6R may represent as a therapeutic target for gastric carcinoma and serve as a prognostic indicator, as well.
本研究的目的是分析白细胞介素-6受体在不同人类胃组织中的表达，并将其与患者的临床病理特征相关联。采用抗IL-6R抗体进行免疫组织化学检测，并根据染色模式计算Q值。肿瘤细胞中的Q值高于相邻正常细胞，具有统计学意义。我们还观察到IL-6R的表达与临床病理特征之间存在显著相关性。这些发现表明，IL-6R可能是胃癌的治疗靶点，也可作为预后指标。
