白细胞介素-6及白细胞介素-6受体表达在口腔鳞状细胞癌中的临床意义

Clinical significance of interleukin-6 and interleukin-6 receptor expressions in oral squamous cell carcinoma.

作者信息

Wang Yi-Fen, Chang Shyue-Yih, Tai Shyh-Kuan, Li Wing-Yin, Wang Liang-Shun

机构信息

Department of Otolaryngology, Taipei-Veterans General Hospital, 201, Sec. 2, Shih-Pai Road, Taipei, Taiwan.

出版信息

Head Neck. 2002 Sep;24(9):850-8. doi: 10.1002/hed.10145.

DOI:10.1002/hed.10145

PMID:12211049

Abstract

BACKGROUND

Recent studies showed that interleukin-6 (IL-6) played a role in tumor development. However, available information about the prognostic significance of IL-6 and IL-6 receptors (IL-6R) for oral squamous cell carcinoma (OSCC) is limited.

METHODS

Eighty-six patients with OSCC were enrolled. Immunohistochemical staining was used to determine IL-6R expression and in-situ hybridization for IL-6 mRNA transcripts in surgical specimens. Clinicopathologic correlation was evaluated by chi-square test and survival by log rank test.

RESULTS

Expression rates of IL-6R and IL-6 mRNA transcripts in tumor specimens were 73.3% and 54.7%, much higher than those in nontumor mucosa (p <.001). IL-6R overexpression was associated with larger tumors and more advanced histologic grade (p <.05). The presence of IL-6 mRNA transcripts was inversely correlated with distant metastasis, lymph node involvement, and second primary SCC (p <.05) and predicted better survival (p =.007).

CONCLUSIONS

IL-6-IL-6R coexpression was rather high in OSCC, and IL-6 mRNA transcript expression might influence patient survival. The biologic role of IL-6-IL-6R coexpression in OSCC needs additional investigation.

摘要

背景

近期研究表明白细胞介素-6（IL-6）在肿瘤发展中发挥作用。然而，关于IL-6和IL-6受体（IL-6R）对口腔鳞状细胞癌（OSCC）预后意义的现有信息有限。

方法

纳入86例OSCC患者。采用免疫组织化学染色确定手术标本中IL-6R的表达，并采用原位杂交检测IL-6 mRNA转录本。通过卡方检验评估临床病理相关性，采用对数秩检验评估生存率。

结果

肿瘤标本中IL-6R和IL-6 mRNA转录本的表达率分别为73.3%和54.7%，远高于非肿瘤黏膜中的表达率（p <.001）。IL-6R过表达与更大的肿瘤和更高的组织学分级相关（p <.05）。IL-6 mRNA转录本的存在与远处转移、淋巴结受累和第二原发性鳞状细胞癌呈负相关（p <.05），并预示着更好的生存率（p =.007）。