Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences , Birjand , Iran.
Department of Clinical Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences , Birjand , Iran.
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2019;54(13):1287-1292. doi: 10.1080/10934529.2019.1640580. Epub 2019 Jul 22.
The aim of this study to the estimate the lead concentrations in the blood of the adult population in South Khorasan Province, evaluate factors related to high lead blood concentrations and establish lead reference values (RVs) in our study population. In cross-sectional study, 400 people who lived in the province of South Khorasan in 2017 were selected. Demographic information was collected and clinical examinations were performed. As the geometric means, blood lead concentration (BLC) was expressed, 10th, 50th, 90th, and 95th percentiles, and 95% confidence intervals (CI) of the 95th percentile. The upper limits rounded values of the 95% CI with the 95th percentile were applied to calculate RVs. Mean BLC was 6.02 ± 7.41 µg dL, median of BLC was 4.4 µg dL (IQR: 2.9-6.5; range 0.9-54.7 µg dL). One hundred and twenty-five (31.2%) participants had BLCs between 5 and 10.0 µg dL, 40 (10.0%) between 10 and 20.0 µg dL, and 15 (3.8%%) over 20 µg dL. The RVs for BLC for men and women were 16 [95% CI: 10.13-15.96] µg dL and 15 [95% CI: 9.81-14.45] µg dL, respectively. Higher BLCs were significantly associated with age, gender, hemoglobin, white blood cell count, and serum phosphorus concentration. This bio-monitoring study of BLCs in the general population of South Khorasan Province offers important demographic and lifestyle factors-stratified reference data. It is essential to continue efforts to reduce lead exposure.
本研究旨在估计南呼罗珊省成年人口的血液铅浓度，评估与高血铅浓度相关的因素，并在研究人群中建立铅参考值（RV）。在横断面研究中，2017 年选择了居住在南呼罗珊省的 400 人。收集了人口统计学信息并进行了临床检查。血铅浓度（BLC）以几何均数、第 10、50、90 和 95 百分位数和 95%置信区间（CI）表示。95%CI 的第 95 百分位上限值用于计算 RV。BLC 的平均值为 6.02 ± 7.41 µg/dL，BLC 的中位数为 4.4 µg/dL（IQR：2.9-6.5；范围 0.9-54.7 µg/dL）。125（31.2%）名参与者的 BLC 为 5-10.0 µg/dL，40（10.0%）为 10-20.0 µg/dL，15（3.8%）为 20 µg/dL 以上。男性和女性的 BLC RV 分别为 16 [95%CI：10.13-15.96] µg/dL 和 15 [95%CI：9.81-14.45] µg/dL。较高的 BLC 与年龄、性别、血红蛋白、白细胞计数和血清磷浓度显著相关。本研究对南呼罗珊省普通人群的 BLC 进行了生物监测，提供了重要的人口统计学和生活方式因素分层参考数据。继续努力减少铅暴露至关重要。
