QOPNA & LAQV-REQUIMTE and Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal.
Photochem Photobiol Sci. 2019 Aug 1;18(8):1910-1922. doi: 10.1039/c9pp00102f. Epub 2019 Jul 22.
New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a β-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a-e. Singlet oxygen studies have demonstrated that all the porphyrin/4-oxoquinoline conjugates 9a-e were capable of producing cytotoxic species and found to be excellent photosensitizing agents in the inactivation of S. aureus by the antimicrobial photodynamic therapy (aPDT) protocol.
新型卟啉/4-氧代喹啉衍生物由β-溴代卟啉与 1-烯丙基-4-氧代喹啉衍生物的 Heck 偶联反应合成，然后进行脱金属和脱保护反应，得到有前途的光敏剂 9a-e。单线态氧研究表明，所有卟啉/4-氧代喹啉衍生物 9a-e 都能够产生细胞毒性物质，并在通过抗菌光动力疗法（aPDT）方案灭活金黄色葡萄球菌方面被发现是优秀的光敏剂。
