Musciano Ayla R, Lanza Matthew R, Dubielzig Richard R, Teixeira Leandro B C, Durham Amy C
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Vet Ophthalmol. 2020 Jan;23(1):77-89. doi: 10.1111/vop.12692. Epub 2019 Jul 22.
This retrospective study aimed to describe and classify cats with intraocular lymphoma, determine the proportion of cases with presumed solitary ocular lymphoma (PSOL) compared with ocular manifestations of multicentric disease and assess the clinical outcomes of these patients. One hundred seventy-two cases identified through biopsy submissions were reviewed histologically; 163 of these cases were subtyped according to the WHO classification system. Cases were categorized as having PSOL or ocular lymphoma with suspected systemic involvement (SSI) based on submission forms and follow-up data. The majority of cases exhibited concurrent uveitis (75%) and secondary glaucoma (58%). Diffuse large B-cell lymphoma was the most common subtype (n = 86; 53%), followed by peripheral T-cell lymphoma (n = 44; 27%). Other subtypes included anaplastic large T- (n = 8; 5%) and B-cell (n = 4; 2.5%) lymphomas, and 15 cases (9%) were negative for all immunohistochemical markers. In sixty-nine cases (40%), adequate clinical data and sufficient survival data were obtained to distinguish PSOL from SSI. PSOL comprised the majority of cases (64%), while 36% had SSI. When covarying for age at diagnosis, the median survival time was significantly higher (P = 0.003) for cases of PSOL (154 days) versus those with SSI (69 days); hazards ratio of 0.47 for PSOL (95% CI: 0.241-0.937). The subtype of lymphoma did not affect survival time. Cats with PSOL represent a greater proportion of the disease population, and this subset of cats with intraocular lymphoma has a better clinical outcome.
这项回顾性研究旨在描述和分类患有眼内淋巴瘤的猫，确定假定的孤立性眼淋巴瘤（PSOL）病例与多中心疾病眼部表现的比例，并评估这些患者的临床结局。对通过活检提交的172例病例进行了组织学检查；其中163例病例根据世界卫生组织分类系统进行了亚型分类。根据提交表格和随访数据，病例被分类为患有PSOL或疑似系统性受累的眼淋巴瘤（SSI）。大多数病例并发葡萄膜炎（75%）和继发性青光眼（58%）。弥漫性大B细胞淋巴瘤是最常见的亚型（n = 86；53%），其次是外周T细胞淋巴瘤（n = 44；27%）。其他亚型包括间变性大T细胞（n = 8；5%）和B细胞（n = 4；2.5%）淋巴瘤，15例（9%）所有免疫组化标记均为阴性。在69例（40%）病例中，获得了足够的临床数据和生存数据，以区分PSOL和SSI。PSOL占大多数病例（64%），而36%患有SSI。在对诊断时的年龄进行协变量分析时，PSOL病例（154天）的中位生存时间显著高于SSI病例（69天）（P = 0.003）；PSOL的风险比为0.47（95%CI：0.241 - 0.937）。淋巴瘤的亚型不影响生存时间。患有PSOL的猫在疾病群体中占更大比例，并且这一患有眼内淋巴瘤的猫亚组具有更好的临床结局。
