Parsons M T, Lindsey R, Palumbo T, Lambert B, Spellacy W N, Wilson L
Department of Obstetrics and Gynecology, University of Illinois, College of Medicine, Chicago 60612.
Am J Perinatol. 1988 Jul;5(3):220-5. doi: 10.1055/s-2007-999689.
Biochemical and biophysical properties of umbilical arteries from normotensive and preeclamptic pregnancies were examined. The production of prostaglandins E and F, 6-keto-PGF1 alpha, and thromboxane B2 by umbilical arteries from normotensive, mildly preeclamptic, and severely preeclamptic pregnancies were measured in incubation media at baseline and after addition of arachidonic acid. The initial baseline values of 6-keto-PGF1 alpha were decreased in the severely preeclamptic patients with intrauterine growth retardation (IUGR) but not in any of the other groups. Addition of arachidonic acid resulted in a significant increase in 6-keto-PGF1 alpha production over initial baseline in all groups except in the severely preeclamptic pregnancies without IUGR. These results suggest a differential defect in the 6-keto-PGF1 alpha metabolic pathway in severely preeclamptic patients with IUGR compared with those without IUGR. The stretch response curve to serotonin was decreased in the severely preeclamptic group with IUGR compared with the control group. The contractile response to individual vasoactive agents (serotonin, prostaglandin F2, norepinephrine, angiotensin II, and arachidonic acid) showed no significant difference between the normotensive and preeclamptic groups.
对正常血压孕妇和先兆子痫孕妇的脐动脉生化及生物物理特性进行了检测。在基线状态下以及添加花生四烯酸后，于孵育培养基中测定了正常血压孕妇、轻度先兆子痫孕妇和重度先兆子痫孕妇的脐动脉中前列腺素E和F、6-酮-前列腺素F1α以及血栓素B2的生成量。重度先兆子痫合并宫内生长受限（IUGR）患者的6-酮-前列腺素F1α初始基线值降低，但其他组均未出现这种情况。除重度先兆子痫且无IUGR的孕妇外，在所有组中，添加花生四烯酸均导致6-酮-前列腺素F1α生成量相较于初始基线值显著增加。这些结果表明，与无IUGR的重度先兆子痫患者相比，重度先兆子痫合并IUGR患者在6-酮-前列腺素F1α代谢途径中存在不同的缺陷。与对照组相比，重度先兆子痫合并IUGR组对5-羟色胺的舒张反应曲线降低。正常血压组和先兆子痫组对各血管活性物质（5-羟色胺、前列腺素F2、去甲肾上腺素、血管紧张素II和花生四烯酸）的收缩反应无显著差异。
