RayBiotech Life, Norcross, Georgia, USA.
RayBiotech Life, Guangzhou, Guangdong, China.
J Leukoc Biol. 2019 Sep;106(3):759-775. doi: 10.1002/JLB.MR1118-440R. Epub 2019 Jul 22.
This review discusses how the measurement of proteins in blood and its components via quantitative proteomics analyses can inform health status. Various external and internal factors such as environmental conditions, genetic background, nutrition, diet, and lifestyle, chronic pathological conditions, disease state, or therapeutic intervention will be investigated and their effects on the protein profile will be shown. The resulting changes to ones' health and how this protein expression information can be used in early screening/diagnostic applications, drug discovery, precision treatment, patient management, and monitoring overall health status will also be presented.
本综述讨论了通过定量蛋白质组学分析测量血液及其成分中的蛋白质如何能够反映健康状况。各种外部和内部因素，如环境条件、遗传背景、营养、饮食和生活方式、慢性病理状况、疾病状态或治疗干预，都将被研究，并展示它们对蛋白质谱的影响。还将介绍这些变化对健康的影响，以及如何将这些蛋白质表达信息应用于早期筛查/诊断应用、药物发现、精准治疗、患者管理和监测整体健康状况。
