School of Materials Science and Engineering and Guangxi Key Lab for Informational Materials, Guilin University of Electronic Technology, Guilin, Guangxi, P. R. China.
Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, Analytical and Testing Center, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, P. R. China.
PLoS One. 2019 Jul 22;14(7):e0220005. doi: 10.1371/journal.pone.0220005. eCollection 2019.
In present work, a highly sensitive biosensor with high selectivity for glucose monitoring is developed based on novel nano-composites of nitrogen doped graphene quantum dots (N-GQDs) and a novel bimetallic Cu/Ni core-shell nanoparticles (CSNPs) (Cu@Ni CSNPs/N-GQDs NCs). With the tuned electronic properties, N-GQDs helped bimetallic core-shell structure nanomaterials from aggregation, and separate the charges generated at the interface. This novel nano-composites also have the good electrical conductivity of N-GQDs, catalyst property of Cu/Ni bimetallic nano composite, Cu@Ni core-shell structure and the synergistic effect of the interaction between bimetallic nano composite and N-GQDs. While modified the electrode with this novel nano-composites, the sensor' linear range is 0.09 ~ 1 mM, and the limit of detection (LOD) is 1.5 μM (S/N = 3) with a high sensitivity of 660 μA mM-1 cm-2, and rapid response time (3 s). Its' LOD is more than 74 times lower than the traditional Cu@Ni CSNPs modified working electrode. It also has higher sensitivity and wider linear range. This indicates the great potential of applying this kind of nano composites in electrode modification.
在目前的工作中，基于新型氮掺杂石墨烯量子点（N-GQDs）和新型双金属 Cu/Ni 核壳纳米粒子（CSNPs）（Cu@Ni CSNPs/N-GQDs NCs）的高度敏感的生物传感器，用于葡萄糖监测，具有高选择性。通过调整电子特性，N-GQDs 有助于双金属核壳结构纳米材料的聚集，并分离界面处产生的电荷。这种新型纳米复合材料还具有 N-GQDs 的良好导电性、Cu/Ni 双金属纳米复合材料的催化性能、Cu@Ni 核壳结构以及双金属纳米复合材料与 N-GQDs 之间相互作用的协同效应。当用这种新型纳米复合材料修饰电极时，传感器的线性范围为 0.09~1 mM，检测限（LOD）为 1.5 μM（S/N = 3），灵敏度为 660 μA mM-1 cm-2，响应时间快（3 s）。其 LOD 比传统的 Cu@Ni CSNPs 修饰工作电极低 74 多倍。它还具有更高的灵敏度和更宽的线性范围。这表明这种纳米复合材料在电极修饰方面具有很大的应用潜力。
