Falageeva D M, Kalashnikov V V
Biull Eksp Biol Med. 1988 May;105(5):583-5.
A new interspecific animal thymus antigen (AgT-2) was identified. It was shown that AgT-2 is a microglobulin with a molecular mass about 12 kDa, electrophoretic mobility of alpha 1-globulins and isoelectric point of 4.6. Heating of the protein to 80 degrees C for 30 min did not lead to the loss of its immunochemical activity. AgT-2 was identified in extracts of bovine fetal thymus, spleen and liver. It was discovered in the extracts of the lung and colon of adult animals. Cross-reactions were found between bovine, walrus, deer and chicken AgT-2. This fact confirms that AgT-2 is interspecies-specific. AgT-2 was not identified in men, dogs, mice, rats and rabbits. Immunochemical research of immunocorrecting preparations revealed that AgT-2 is a constant component of T-activin, thymalin, thymosin and TP1-Serono and its concentration varies from 1.6 to 3.2%. It has been stated that immunochemical test for AgT-2 can be used as a marker in the production and standardization of active thymus factors.
