Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Electrical and Electronics Engineering, Istanbul Arel University, Istanbul, Turkey.
Muscle Nerve. 2019 Oct;60(4):400-408. doi: 10.1002/mus.26644. Epub 2019 Aug 5.
The objective of this study was to determine compound muscle action potential (CMAP) scan parameters and MScanFit motor unit number estimation (MUNE) in patients with amyotrophic lateral sclerosis (ALS) and to compare the results in the abductor pollicis brevis (APB) to those in the abductor digiti minimi (ADM).
CMAP scans were recorded from the APB and ADM in 35 patients with ALS and 21 controls. MScanFit MUNE, neurophysiological index (NI), step%, returner%, and D50 were calculated.
CMAP scan parameters including the returner%, MScanFit MUNE, and NI can distinguish ALS with high sensitivity and specificity. The electrophysiological parameters, with the exception of D50 (the number of largest consecutive differences of recorded responses generating 50% of maximum CMAP), showed more pronounced changes in the APB than in the ADM, even though most of the patients had normal APB/ADM amplitude ratios.
CMAP scan parameters and MScanFit MUNE can be used in the evaluation of denervation and reinnervation and may herald the "split hand" in ALS.
本研究旨在确定肌电图复合肌肉动作电位（CMAP）扫描参数和 MScanFit 运动单位数量估计（MUNE）在肌萎缩侧索硬化症（ALS）患者中的表现，并比较拇短展肌（APB）和小指展肌（ADM）的结果。
对 35 例 ALS 患者和 21 例对照者的 APB 和 ADM 进行 CMAP 扫描记录。计算 MScanFit MUNE、神经生理指数（NI）、步长%、返回率%和 D50。
CMAP 扫描参数，包括返回率%、MScanFit MUNE 和 NI，具有较高的灵敏度和特异性，可用于区分 ALS。除了 D50（记录的反应中最大连续差异的数量，产生最大 CMAP 的 50%）外，电生理参数在 APB 中的变化比在 ADM 中更为明显，尽管大多数患者的 APB/ADM 幅度比正常。
CMAP 扫描参数和 MScanFit MUNE 可用于评估去神经支配和再支配，并可能预示 ALS 的“手部分离”。
