表面肌电图在肌萎缩侧索硬化症中的作用演变：系统评价。
The evolving role of surface electromyography in amyotrophic lateral sclerosis: A systematic review.
机构信息
UK Dementia Research Institute, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK. Electronic address: https://spiqe.co.uk.
UK Dementia Research Institute, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
出版信息
Clin Neurophysiol. 2020 Apr;131(4):942-950. doi: 10.1016/j.clinph.2019.12.007. Epub 2019 Dec 27.
OBJECTIVE
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease that leads to inexorable motor decline and a median survival of three years from symptom onset. Surface EMG represents a major technological advance that has been harnessed in the development of novel neurophysiological biomarkers. We have systematically reviewed the current application of surface EMG techniques in ALS.
METHODS
We searched PubMed to identify 42 studies focusing on surface EMG and its associated analytical methods in the diagnosis, prognosis and monitoring of ALS patients.
RESULTS
A wide variety of analytical techniques were identified, involving motor unit decomposition from high-density grids, motor unit number estimation and measurements of neuronal hyperexcitability or neuromuscular architecture. Some studies have proposed specific diagnostic and prognostic criteria however clinical calibration in large ALS cohorts is currently lacking. The most validated method to monitor disease is the motor unit number index (MUNIX), which has been implemented as an outcome measure in two ALS clinical trials.
CONCLUSION
Surface EMG offers significant practical and analytical flexibility compared to invasive techniques. To capitalise on this fully, emphasis must be placed upon the multi-disciplinary collaboration of clinicians, bioengineers, mathematicians and biostatisticians.
SIGNIFICANCE
Surface EMG techniques can enrich effective biomarker development in ALS.
目的
肌萎缩侧索硬化症（ALS）是一种成人发病的神经退行性疾病，会导致运动功能不可避免地衰退，从症状出现到中位生存期为 3 年。表面肌电图是一项重大技术进步，已被应用于新型神经生理生物标志物的开发。我们系统地回顾了表面肌电图技术在 ALS 中的当前应用。
方法
我们在 PubMed 上搜索了 42 项专注于表面肌电图及其相关分析方法在 ALS 患者诊断、预后和监测中的应用的研究。
结果
确定了广泛的分析技术，涉及高密度网格中的运动单位分解、运动单位数量估计以及神经元过度兴奋或神经肌肉结构的测量。一些研究提出了特定的诊断和预后标准，但目前缺乏在大型 ALS 队列中进行临床校准。监测疾病最有效的方法是运动单位数量指数（MUNIX），它已被纳入两项 ALS 临床试验的结果衡量标准。
结论
与侵入性技术相比，表面肌电图具有显著的实际和分析灵活性。要充分利用这一点，必须强调临床医生、生物工程师、数学家和生物统计学家的多学科合作。
意义
表面肌电图技术可以丰富 ALS 中有效的生物标志物开发。
Zotero 插件