Eris Lifesciences , Plot Nos. 30 and 31, Brahmaputra Industrial Park, Amingaon, North Guwahati , Guwahati , Assam 781031 , India.
Department of Chemistry , Indian Institute of Technology Guwahati , Assam - 781039 , India.
Langmuir. 2019 Aug 20;35(33):10704-10724. doi: 10.1021/acs.langmuir.9b01837. Epub 2019 Aug 8.
Peptide amphiphiles (PAs) are extremely attractive as molecular building blocks, especially in the bottom-up fabrication of supramolecular soft materials, and have potential in many important applications across various fields of science and technology. In recent years, we have designed and synthesized a large group of peptide amphiphiles. This library of PAs has the ability to self-assemble into a variety of aggregates such as fibers, nanosphere, vesicles, nanosheet, nanocups, nanorings, hydrogels, and so on. The mechanism behind the formation of such a wide range of structures is intriguing. Each system has its individual method of aggregation and results in assemblies with important applications in areas including chemistry, biology, and materials science. The aim of this feature article is to bring together our recent achievements with designer PAs with respect to their self-assembly processes and applications. Emphasis is placed on rational design, mechanistic aspects of the self-assembly processes, and the applications of these PAs. We hope that this article will provide a conceptual demonstration of the different approaches taken toward the construction of these task-specific PAs.
肽两亲物（PAs）作为分子构建模块极具吸引力，特别是在自下而上构建超分子软物质方面，在科学技术的各个领域的许多重要应用中都具有潜力。近年来，我们设计并合成了一大组肽两亲物。这些 PA 库能够自组装成各种聚集体，如纤维、纳米球、囊泡、纳米片、纳米杯、纳米环、水凝胶等。形成如此广泛结构的机制令人着迷。每个系统都有其独特的聚集方法，并产生了在化学、生物学和材料科学等领域具有重要应用的组装体。本文的目的是将我们最近在设计 PA 的自组装过程和应用方面的成果汇集在一起。重点放在自组装过程的合理设计、机械方面以及这些 PA 的应用上。我们希望本文将为构建这些特定任务的 PA 提供不同方法的概念性演示。
