Academic Unit of Psychiatry and Addiction Medicine, the Australian National University Medical School, Canberra Hospital, Yamba Drive, Garran, ACT 2605, Australia.
Imaging Genetics Center, Department of Neurology, Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, 4676 Admiralty Way, Ste. 200, Health Sciences Campus, Marina del Rey, CA, USA.
Psychiatry Res Neuroimaging. 2019 Sep 30;291:1-8. doi: 10.1016/j.pscychresns.2019.07.003. Epub 2019 Jul 12.
We aimed to investigate the relationship between striatal morphology in Huntington disease (HD) and measures of motor and cognitive dysfunction. MRI scans, from the IMAGE-HD study, were obtained from 36 individuals with pre-symptomatic HD (pre-HD), 37 with early symptomatic HD (symp-HD), and 36 healthy matched controls. The neostriatum was manually segmented and a surface-based parametric mapping protocol derived two pointwise shape measures: thickness and surface dilation ratio. Significant shape differences were detected between all groups. Negative associations were detected between lower thickness and surface area shape measure and CAG repeats, disease burden score, and UHDRS total motor score. In symp-HD, UPSIT scores were correlated with higher thickness in left caudate tail and surface dilation ratio in left posterior putamen; Stroop scores were positively correlated with the thickness of left putamen head and body. Self-paced tapping (slow) was correlated with higher thickness and surface dilation ratio in the right caudate in symp-HD and with bilateral putamen in pre-HD. Self-paced tapping (fast) was correlated with higher surface dilation ratio in the right anterior putamen in symp-HD. Shape changes correlated with functional measures subserved by corticostriatal circuits, suggesting that the neostriatum is a potentially useful structural basis for characterisation of endophenotypes of HD.
我们旨在研究亨廷顿病（HD）纹状体形态与运动和认知功能障碍测量值之间的关系。从 IMAGE-HD 研究中获得了 36 名处于前驱期 HD（pre-HD）的个体、37 名处于早期症状期 HD（symp-HD）的个体和 36 名健康匹配对照者的 MRI 扫描。手动分割新纹状体，并采用基于表面的参数映射方案得出了两个点状形状测量值：厚度和表面扩张比。在所有组之间均检测到明显的形状差异。厚度和表面积形状测量值与 CAG 重复次数、疾病负担评分和 UHDRS 总运动评分呈负相关。在 symp-HD 中，UPSIT 评分与左侧尾状核头和左侧壳核后部的厚度增加以及表面扩张比呈正相关；Stroop 评分与左侧壳核头和体的厚度呈正相关。自我调节的轻敲（慢）与 symp-HD 右侧尾状核中的厚度和表面扩张比增加以及 pre-HD 双侧壳核的厚度和表面扩张比增加相关。自我调节的轻敲（快）与 symp-HD 右侧壳核前部的表面扩张比增加呈正相关。与皮质纹状体回路所介导的功能测量值相关的形状变化表明，新纹状体是对 HD 内表型进行特征描述的潜在有用的结构基础。
