Department of Dermatology, China-Japan Union Hospital, Jilin University, Changchun, China.
Department of Pharmacology, Toxicology & Neurosciences, LSU Health Sciences Center, Shreveport, LA, USA.
FEBS Lett. 2019 Sep;593(18):2525-2534. doi: 10.1002/1873-3468.13546. Epub 2019 Aug 1.
Mitochondria are the primary sites for ATP synthesis and free radical generation in organisms. Abnormal mitochondrial metabolism contributes to many diseases, including obesity, diabetes and cancer. UCP2 is an ion/anion transporter located in mitochondrial inner membrane, and has a crucial role in regulating oxidative stress, cellular metabolism, cell proliferation and cell death. Polymorphisms of the UCP2 gene have been associated with diabetes and obesity because UCP2 is involved in energy expenditure and insulin secretion. Moreover, UCP2 gene expression is often amplified in cancers, and increased UCP2 expression contributes to cancer growth, cancer metabolism, anti-apoptosis and drug resistance. The present review summarizes the latest findings of UCP2 with respect to obesity, diabetes and cancer.
线粒体是生物体中 ATP 合成和自由基生成的主要场所。异常的线粒体代谢导致许多疾病，包括肥胖、糖尿病和癌症。UCP2 是一种位于线粒体内膜的离子/阴离子转运体，在调节氧化应激、细胞代谢、细胞增殖和细胞死亡方面发挥着关键作用。UCP2 基因的多态性与糖尿病和肥胖有关，因为 UCP2 参与能量消耗和胰岛素分泌。此外，UCP2 基因表达在癌症中经常被放大，增加的 UCP2 表达有助于癌症生长、癌症代谢、抗凋亡和耐药性。本综述总结了 UCP2 在肥胖、糖尿病和癌症方面的最新发现。
