Department of Surgical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Nutrients. 2019 Jul 19;11(7):1651. doi: 10.3390/nu11071651.
Available evidence on the associations of dietary and circulating levels of long-chain n-3 fatty acids, which have potential antiarrhythmic properties, and other fatty acids with atrial fibrillation is conflicting and limited. We conducted a Mendelian randomization study to assess the associations between plasma phospholipid fatty acid levels and atrial fibrillation. Summary-level data of atrial fibrillation were available from 65,446 cases and 522,744 non-cases included in the Atrial Fibrillation Consortium. Sixteen single-nucleotide polymorphisms associated with ten fatty acids at significance level of < 5 × 10 were identified as instrumental variables from the hitherto largest genome-wide association studies for plasma fatty acids. The fixed-effects inverse-variance weighted method was used to assess the association of individual plasma fatty acids and atrial fibrillation risk. The random-effects inverse-variance weighted method, weighted median method, and Mendelian randomization (MR)-Egger method were employed as the sensitivity analyses. Genetic predisposition to higher levels of any of the ten individual fatty acids was not associated with atrial fibrillation risk.
目前关于长链 n-3 脂肪酸（具有潜在抗心律失常特性）和其他脂肪酸与心房颤动之间关联的饮食和循环水平的证据存在矛盾且有限。我们进行了一项孟德尔随机化研究，以评估血浆磷脂脂肪酸水平与心房颤动之间的关联。心房颤动的汇总水平数据可从包含在心房颤动联盟中的 65446 例病例和 522744 例非病例中获得。从迄今为止最大的血浆脂肪酸全基因组关联研究中，确定了 16 个与十种脂肪酸相关的单核苷酸多态性，这些多态性在 < 5 × 10 水平上具有显著意义，可作为工具变量。采用固定效应逆方差加权法评估个体血浆脂肪酸与心房颤动风险的关联。采用随机效应逆方差加权法、加权中位数法和孟德尔随机化（MR-Egger）法进行敏感性分析。遗传易感性导致任何十种个体脂肪酸水平升高与心房颤动风险无关。
