Pavelková Miroslava, Vysloužil Jakub, Kubová Kateřina, Pavloková Sylvie, Mašková Eliška, Vetchý David
Ceska Slov Farm. 2019 Summer;68(2):69-77.
Currently, the method of external ionic gelation for the preparation of alginate particles is successfully used not only in the field of pharmacy and medicine, but also especially in the field of biotechnology. Therefore, the preparation of alginate particles and their subsequent evaluation using principal component analysis was the key task of our experiment. To optimize this method, we focused on the evaluation of the effect of formulation (the polymer concentration, the hardening solution concentration) and process parameters (the outer diameter of the injection needle) on the properties of the resulting beads (yield, sphericity factor, equivalent diameter and swelling capacity at pH 6). Using multivariate data analysis, the major influence on the resulting properties of the prepared particles was confirmed only in sodium alginate concentration. Obtained results verified the reliable and safe potential of the external ionic gelation for preparation alginate-based particulate dosage forms.
目前，用于制备藻酸盐颗粒的外部离子凝胶法不仅成功应用于制药和医学领域，而且特别在生物技术领域也得到了应用。因此，制备藻酸盐颗粒并随后使用主成分分析进行评估是我们实验的关键任务。为了优化该方法，我们重点评估了配方（聚合物浓度、硬化溶液浓度）和工艺参数（注射针外径）对所得微球性质（产率、球形度因子、等效直径和pH 6时的溶胀能力）的影响。通过多变量数据分析，证实仅海藻酸钠浓度对制备颗粒的最终性质有主要影响。所得结果验证了外部离子凝胶法在制备藻酸盐基颗粒剂型方面的可靠和安全潜力。
