Sun Chuan-Bin, Wang Yueye, Zhou Shiyang, Fang Xudong, Xu Danni, Liu Zhe
Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
Department of Ophthalmology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 310015, China.
BMC Ophthalmol. 2019 Jul 22;19(1):156. doi: 10.1186/s12886-019-1164-4.
We report a case of macular hole (MH) formation and retinal detachment after intravitreal conbercept injection for the treatment of choroidal neovascularization (CNV) secondary to degenerative myopia.
A 60-year-old woman presented with blurred vision in her left eye was diagnosed as CNV secondary to degenerative myopia. Intravitreal injection of conbercept, an anti -vascular endothelial growth factor (VEGF) agent, was uneventfully performed in the left eye. Unfortunately, a full thickness MH and retinal detachment was found three weeks postoperatively by ophthalmoscopy and spectral-domain optical coherence tomography. Vitrectomy, internal limiting membrane peeling and silicone oil tamponade were then performed, and macular retina was reattached soon after surgery. However, MH still kept open during three months' follow-up.
MH is a quite rare complication of intravitreal anti- VEGF agent injection, tangential contraction secondary to CNV shrinkage and regression caused by anti-VEGF agent is proposed to be the major pathogenesis of MH formation.
我们报告一例在玻璃体腔内注射康柏西普治疗变性近视继发脉络膜新生血管（CNV）后出现黄斑裂孔（MH）形成和视网膜脱离的病例。
一名60岁女性因左眼视力模糊就诊，被诊断为变性近视继发CNV。左眼顺利进行了玻璃体腔内注射抗血管内皮生长因子（VEGF）药物康柏西普。不幸的是，术后三周通过检眼镜检查和光谱域光学相干断层扫描发现了全层MH和视网膜脱离。随后进行了玻璃体切除术、内界膜剥除术和硅油填充术，术后黄斑视网膜很快复位。然而，在三个月的随访期间MH仍未闭合。
MH是玻璃体腔内注射抗VEGF药物极为罕见的并发症，抗VEGF药物导致的CNV收缩和消退继发的切线方向收缩被认为是MH形成的主要发病机制。
