TNF 阻断剂有助于恢复幼年特发性关节炎患儿运动时的脂质氧化。
TNF blockade contributes to restore lipid oxidation during exercise in children with juvenile idiopathic arthritis.
机构信息
CHU Clermont-Ferrand, Pédiatrie, Hôpital Estaing, F-63000, Clermont-Ferrand, France.
Université Clermont Auvergne, INSERM, CIC 1405, Unité CRECHE, F-63000, Clermont-Ferrand, France.
出版信息
Pediatr Rheumatol Online J. 2019 Jul 22;17(1):47. doi: 10.1186/s12969-019-0354-1.
BACKGROUND
Children with juvenile idiopathic arthritis (JIA) have impaired physical abilities. TNF-α plays a crucial role in this pathogenesis, but it is also involved in the use of lipids and muscle health. Objective of this study was to explore substrate oxidation and impact of TNF blockade on energy metabolism in children with JIA as compared to healthy children.
METHODS
Fifteen non-TNF-blockaded and 15 TNF-blockaded children with JIA and 15 healthy controls were matched by sex, age, and Tanner stage. Participants completed a submaximal incremental exercise test on ergocycle to determine fat and carbohydrate oxidation rates by indirect calorimetry.
RESULTS
The maximal fat oxidation rate during exercise was lower in JIA children untreated by TNF blockade (134.3 ± 45.2 mg.min) when compared to the controls (225.3 ± 92.9 mg.min, p = 0.007); but was higher in JIA children under TNF blockade (163.2 ± 59.0 mg.min, p = 0.31) when compared to JIA children untreated by TNF blockade. At the same relative exercise intensities, there was no difference in carbohydrate oxidation rate between three groups.
CONCLUSIONS
Lipid metabolism during exercise was found to be impaired in children with JIA. However, TNF treatment seems to improve the fat oxidation rate in this population.
TRIAL REGISTRATION
In ClinicalTrials.gov, reference number NCT02977416 , registered on 30 November 2016.
背景
儿童幼年特发性关节炎（JIA）患者的身体机能受损。TNF-α 在这种发病机制中起着至关重要的作用，但它也参与了脂质和肌肉健康的利用。本研究的目的是探讨与健康儿童相比，JIA 儿童的底物氧化和 TNF 阻断对能量代谢的影响。
方法
15 名未接受 TNF 阻断治疗的 JIA 儿童和 15 名接受 TNF 阻断治疗的 JIA 儿童以及 15 名健康对照者按性别、年龄和 Tanner 分期相匹配。参与者在测功计上完成亚最大递增运动试验，通过间接测热法确定脂肪和碳水化合物的氧化率。
结果
与对照组（225.3 ± 92.9 mg.min，p = 0.007）相比，未接受 TNF 阻断治疗的 JIA 儿童（134.3 ± 45.2 mg.min）在运动时的最大脂肪氧化率较低；但接受 TNF 阻断治疗的 JIA 儿童（163.2 ± 59.0 mg.min，p = 0.31）高于未接受 TNF 阻断治疗的 JIA 儿童。在相同的相对运动强度下，三组间碳水化合物氧化率无差异。
结论
在 JIA 儿童中，运动时的脂质代谢被发现受损。然而，TNF 治疗似乎可以提高该人群的脂肪氧化率。
试验注册
ClinicalTrials.gov，注册号 NCT02977416，于 2016 年 11 月 30 日注册。
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