School of Pharmacy, Nanjing Medical University, Nanjing, China.
School of Pharmacy, Nanjing Medical University, Nanjing, China.
Adv Clin Chem. 2019;91:123-162. doi: 10.1016/bs.acc.2019.03.004. Epub 2019 May 10.
HER2-positive breast cancer is a particularly aggressive type of breast cancer. Indication of HER2 positivity is essential for its treatment. In addition to a few FDA-approved methods such as immunohistochemical (IHC) detection of HER2 protein expression and in situ hybridization (ISH) assessment of HER2 gene amplification, several novel methods have been developed for HER2 testing in recent years. This chapter provides an overview of HER2 testing with emphasis on those new methods.
人表皮生长因子受体 2 阳性乳腺癌是一种侵袭性较强的乳腺癌。HER2 阳性的检测对其治疗至关重要。除了少数 FDA 批准的方法，如免疫组织化学（IHC）检测 HER2 蛋白表达和原位杂交（ISH）评估 HER2 基因扩增外，近年来还开发了几种新的 HER2 检测方法。本章重点介绍了这些新方法，概述了 HER2 检测。
