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皮质听觉诱发电位评估新生儿:足月和早产儿最低反应水平的研究。

Cortical auditory evoked potential in assessment of neonates: a study about minimum level of responses in term and preterm newborns.

机构信息

Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Porto Alegre, RS, Brazil.

Santa Casa de São Paulo, Faculdade de Ciências Médicas, São Paulo, SP, Brazil.

出版信息

Braz J Otorhinolaryngol. 2020 Nov-Dec;86(6):687-695. doi: 10.1016/j.bjorl.2019.04.009. Epub 2019 Jul 4.

Abstract

INTRODUCTION

The study of the threshold level of cortical auditory response in adults has been investigated in previous studies. Due to maturational issues, little is known about these responses in neonates. Technological advances with automatic analysis devices now allow investigation in specific populations. Thus, new studies are needed to establish the feasibility of using this auditory potential to identify the lowest levels of responses in children.

OBJECTIVE

Verify and compare latency and amplitude in 80dBnNA and the minimum level of cortical auditory response in term and preterm neonates.

METHODS

A cross-sectional, comparative study involving 59 neonates, 35 full-term births and 24 preterm births, with positive results in the Neonatal Hearing Screening. The Hearlab system was used to investigate the P1i auditory potential with tone burst stimulus at frequencies of 500, 1000, 2000 and 4000Hz. The minimum response level search ranged from 80 to 0dBNA and was detected automatically. The results were compared between groups, evaluating the latency and amplitude in 80dBNA and the minimum level of cortical auditory response.

RESULTS

The mean values obtained for the minimum level of cortical auditory response in term group were 26±8.81; 26.14±6.97; 29±7.65 and 29.43±7.04dBNA and for preterm neonates of 31.96±10.41; 34.13±11.34; 33.64±11.03 and 37.73±11.92dBNA, for the frequencies of 500, 1000, 2000 and 4000Hz, respectively. There was a difference between groups for the latency of P1i at 4000Hz and the minimum response levels at 500, 1000 and 4000Hz, with higher values for preterm infants.

CONCLUSION

It was possible to obtain latency and amplitude values at 80dBnNA and the minimum level of cortical response in term and preterm newborns, with different results between groups, with higher values in those born preterm.

摘要

引言

先前的研究已经探讨了成年人皮质听觉反应阈限水平的研究。由于发育问题,对于新生儿的这些反应知之甚少。随着自动分析设备的技术进步,现在可以针对特定人群进行研究。因此,需要开展新的研究来确定使用这种听觉潜能来识别儿童最低反应水平的可行性。

目的

验证并比较足月和早产儿在 80dBnNA 时的潜伏期和振幅,以及皮质听觉反应的最低水平。

方法

这是一项横断面、比较性研究,共纳入 59 名新生儿,其中 35 名为足月产,24 名为早产,且新生儿听力筛查结果均为阳性。使用 Hearlab 系统,以 500、1000、2000 和 4000Hz 的纯音刺激来检测 P1i 听觉潜能。最低反应水平的搜索范围为 80 至 0dBNA,并自动检测。对各组结果进行比较,评估 80dBNA 时的潜伏期和振幅,以及皮质听觉反应的最低水平。

结果

在足月组中,皮质听觉反应最低水平的平均值分别为 500Hz 时 26±8.81dBNA、1000Hz 时 26.14±6.97dBNA、2000Hz 时 29±7.65dBNA 和 4000Hz 时 29.43±7.04dBNA;早产儿的相应值分别为 500Hz 时 31.96±10.41dBNA、1000Hz 时 34.13±11.34dBNA、2000Hz 时 33.64±11.03dBNA 和 4000Hz 时 37.73±11.92dBNA。在 4000Hz 时 P1i 的潜伏期和 500、1000 和 4000Hz 的最低反应水平存在组间差异,早产儿的潜伏期和最低反应水平较高。

结论

可以在足月和早产儿中获得 80dBnNA 时的潜伏期和振幅值,以及皮质反应的最低水平,且组间结果不同,早产儿的潜伏期和最低反应水平较高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ab/9422710/d8b4cbeaa65a/gr1.jpg

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