Karolinska Institute, Department of Cell and Molecular Biology, Biomedicum, Solnavägen 9, 17163 Stockolm, Sweden.
Karolinska Institute, Department of Cell and Molecular Biology, Biomedicum, Solnavägen 9, 17163 Stockolm, Sweden
Development. 2019 Jul 22;146(14):dev167700. doi: 10.1242/dev.167700.
Salamanders have been hailed as champions of regeneration, exhibiting a remarkable ability to regrow tissues, organs and even whole body parts, e.g. their limbs. As such, salamanders have provided key insights into the mechanisms by which cells, tissues and organs sense and regenerate missing or damaged parts. In this Primer, we cover the evolutionary context in which salamanders emerged. We outline the varieties of mechanisms deployed during salamander regeneration, and discuss how these mechanisms are currently being explored and how they have advanced our understanding of animal regeneration. We also present arguments about why it is important to study closely related species in regeneration research.
蝾螈被誉为再生的冠军，具有非凡的能力来再生组织、器官甚至整个身体部位，例如它们的四肢。因此，蝾螈为我们了解细胞、组织和器官如何感知和再生缺失或受损的部分提供了关键的见解。在这篇概述中，我们涵盖了蝾螈出现的进化背景。我们概述了在蝾螈再生过程中部署的各种机制，并讨论了这些机制目前如何被探索，以及它们如何推动了我们对动物再生的理解。我们还提出了一些观点，说明为什么在再生研究中密切研究相关物种是很重要的。
