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替加环素-环丙沙星联合治疗对创伤弧菌败血症的协同作用和活性。

Synergy and Activity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis.

机构信息

Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.

Department of Biomedical Science, Chonnam National University Medical School, Gwangju, Republic of Korea.

出版信息

Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.00310-19. Print 2019 Oct.

DOI:10.1128/AAC.00310-19
PMID:31332060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6761547/
Abstract

The mortality rate associated with sepsis remains high. An time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, combination treatment with tigecycline-ciprofloxacin may be an effective novel antibiotic regimen for sepsis.

摘要

脓毒症相关的死亡率仍然很高。时间杀菌试验显示替加环素与环丙沙星之间具有协同作用。替加环素联合环丙沙星治疗组的存活率显著高于头孢噻肟联合米诺环素治疗组。因此，替加环素联合环丙沙星的联合治疗可能是一种有效的治疗脓毒症的新型抗生素方案。

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本文引用的文献

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Efficacy of Ceftriaxone, Cefepime, Doxycycline, Ciprofloxacin, and Combination Therapy for Vibrio vulnificus Foodborne Septicemia.头孢曲松、头孢吡肟、强力霉素、环丙沙星和联合治疗创伤弧菌食源性败血症的疗效。
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01106-17. Print 2017 Dec.
2
Pharmacokinetics and Pharmacodynamics of Minocycline against Acinetobacter baumannii in a Neutropenic Murine Pneumonia Model.米诺环素在中性粒细胞减少小鼠肺炎模型中对鲍曼不动杆菌的药代动力学和药效学
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02371-16. Print 2017 May.
3
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The Biology of Vibrio vulnificus.创伤弧菌的生物学特性。
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