替加环素-环丙沙星联合治疗对创伤弧菌败血症的协同作用和活性。
Synergy and Activity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis.
机构信息
Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Republic of Korea.
Department of Biomedical Science, Chonnam National University Medical School, Gwangju, Republic of Korea.
出版信息
Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.00310-19. Print 2019 Oct.
Abstract
The mortality rate associated with sepsis remains high. An time-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, combination treatment with tigecycline-ciprofloxacin may be an effective novel antibiotic regimen for sepsis.
摘要
脓毒症相关的死亡率仍然很高。时间杀菌试验显示替加环素与环丙沙星之间具有协同作用。替加环素联合环丙沙星治疗组的存活率显著高于头孢噻肟联合米诺环素治疗组。因此，替加环素联合环丙沙星的联合治疗可能是一种有效的治疗脓毒症的新型抗生素方案。
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