一种新型广谱抗菌组合药物，用于治疗绿脓杆菌性角膜感染。
A Novel, Broad-Spectrum Antimicrobial Combination for the Treatment of Pseudomonas aeruginosa Corneal Infections.
机构信息
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
出版信息
Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.00777-19. Print 2019 Oct.
Abstract
Bacterial keratitis causes significant blindness, yet antimicrobial resistance has rendered current treatments ineffective. Polymyxin B-trimethoprim (PT) plus rifampin has potent activity against and , two important causes of keratitis. Here we further characterize this combination against in a murine keratitis model. PT plus rifampin performed comparably to or better than moxifloxacin, the gold standard, suggesting that the combination may be a promising therapy for bacterial keratitis.
摘要
细菌性角膜炎可导致严重失明，但抗菌药物耐药性已使目前的治疗方法失效。多粘菌素 B-三甲氧苄啶（PT）加利福平对 和 具有很强的活性，这两种是角膜炎的重要病因。在这里，我们在小鼠角膜炎模型中进一步研究了这种联合用药对 的作用。PT 加利福平的疗效与莫西沙星（金标准）相当或更好，这表明该联合用药可能是治疗细菌性角膜炎的一种有前途的疗法。
相似文献
1
A Novel, Broad-Spectrum Antimicrobial Combination for the Treatment of Pseudomonas aeruginosa Corneal Infections.一种新型广谱抗菌组合药物，用于治疗绿脓杆菌性角膜感染。
Antimicrob Agents Chemother. 2019 Sep 23;63(10). doi: 10.1128/AAC.00777-19. Print 2019 Oct.
2
Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections.广谱抗菌组合药物的开发用于治疗金黄色葡萄球菌和铜绿假单胞菌角膜感染。
Antimicrob Agents Chemother. 2018 Dec 21;63(1). doi: 10.1128/AAC.01929-18. Print 2019 Jan.
3
The use of antimicrobial peptides in ophthalmology: an experimental study in corneal preservation and the management of bacterial keratitis.抗菌肽在眼科的应用：角膜保存及细菌性角膜炎治疗的实验研究
Trans Am Ophthalmol Soc. 2002;100:243-71.
4
Effectiveness of mupirocin and polymyxin B in experimental Staphylococcus aureus, Pseudomonas aeruginosa, and Serratia marcescens keratitis.莫匹罗星和多粘菌素B在实验性金黄色葡萄球菌、铜绿假单胞菌和粘质沙雷氏菌角膜炎中的有效性。
Cornea. 2002 Nov;21(8):807-11. doi: 10.1097/00003226-200211000-00016.
5
Antimicrobial Activity of a Triple Antibiotic Combination Toward Ocular Pseudomonas aeruginosa Clinical Isolates.三联抗生素组合对眼部铜绿假单胞菌临床分离株的抗菌活性。
Transl Vis Sci Technol. 2022 May 2;11(5):26. doi: 10.1167/tvst.11.5.26.
6
Comparative efficacy of topical moxifloxacin versus ciprofloxacin and vancomycin in the treatment of P. aeruginosa and ciprofloxacin-resistant MRSA keratitis in rabbits.局部用莫西沙星与环丙沙星和万古霉素治疗兔铜绿假单胞菌及耐环丙沙星耐甲氧西林金黄色葡萄球菌角膜炎的疗效比较
Cornea. 2005 Mar;24(2):201-5. doi: 10.1097/01.ico.0000134462.88535.d0.
7
Characterization of virulence factors, antimicrobial resistance patterns and biofilm formation of Pseudomonas aeruginosa and Staphylococcus spp. strains isolated from corneal infection.从角膜感染中分离出的铜绿假单胞菌和葡萄球菌菌株的毒力因子、抗菌药物耐药模式及生物膜形成特性
J Fr Ophtalmol. 2018 Nov;41(9):823-829. doi: 10.1016/j.jfo.2018.01.012. Epub 2018 Oct 3.
8
A comparison of topical chlorhexidine, ciprofloxacin, and fortified tobramycin/cefazolin in rabbit models of Staphylococcus and Pseudomonas keratitis.在葡萄球菌性和铜绿假单胞菌性角膜炎兔模型中，局部应用洗必泰、环丙沙星以及强化妥布霉素/头孢唑林的比较。
J Ocul Pharmacol Ther. 2007 Jun;23(3):213-20. doi: 10.1089/jop.2006.81.
9
Bactericidal effect of photo-activated riboflavin using UVA.使用紫外线A的光活化核黄素的杀菌作用
Graefes Arch Clin Exp Ophthalmol. 2010 May;248(5):755; author reply 757-8. doi: 10.1007/s00417-009-1281-5. Epub 2010 Jan 21.
10
A laboratory evaluation of antibiotic therapy for ciprofloxacin-resistant Pseudomonas aeruginosa.环丙沙星耐药铜绿假单胞菌抗生素治疗的实验室评估
Am J Ophthalmol. 2004 Aug;138(2):226-30. doi: 10.1016/j.ajo.2004.03.016.
引用本文的文献
1
Characterization of vanA-harboring plasmids supports differentiation of outbreak-related and sporadic vancomycin-resistant Enterococcus faecium isolates in a tertiary care hospital.携带vanA基因的质粒的特征分析有助于区分三级护理医院中与暴发相关的和散发的耐万古霉素屎肠球菌分离株。
BMC Microbiol. 2025 May 28;25(1):337. doi: 10.1186/s12866-025-04058-5.
2
and P infectious keratitis: key bacterial mechanisms that mediate pathogenesis and emerging therapeutics.并探讨 P 型感染性角膜炎：介导发病机制的关键细菌机制和新兴治疗方法。
Front Cell Infect Microbiol. 2023 Aug 21;13:1250257. doi: 10.3389/fcimb.2023.1250257. eCollection 2023.
3
Antimicrobial Drug-Drug Interactions in the Treatment of Infectious Keratitis.治疗感染性角膜炎的抗菌药物药物相互作用。
Cornea. 2023 Dec 1;42(12):1555-1561. doi: 10.1097/ICO.0000000000003304. Epub 2023 Apr 27.
4
Antimicrobial Activity of a Triple Antibiotic Combination Toward Ocular Pseudomonas aeruginosa Clinical Isolates.三联抗生素组合对眼部铜绿假单胞菌临床分离株的抗菌活性。
Transl Vis Sci Technol. 2022 May 2;11(5):26. doi: 10.1167/tvst.11.5.26.
5
Efficacy of a Novel Ophthalmic Antimicrobial Drug Combination Toward a Large Panel of Staphylococcus aureus Clinical Ocular Isolates From Around the World.一种新型眼科抗菌药物组合对来自世界各地的大量金黄色葡萄球菌临床眼部分离株的疗效。
Cornea. 2020 Oct;39(10):1278-1284. doi: 10.1097/ICO.0000000000002414.
本文引用的文献
1
Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections.广谱抗菌组合药物的开发用于治疗金黄色葡萄球菌和铜绿假单胞菌角膜感染。
Antimicrob Agents Chemother. 2018 Dec 21;63(1). doi: 10.1128/AAC.01929-18. Print 2019 Jan.
2
Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes.多粘菌素：抗菌活性、药敏试验以及由质粒或染色体编码的耐药机制
Clin Microbiol Rev. 2017 Apr;30(2):557-596. doi: 10.1128/CMR.00064-16.
3
Bacterial Spectrum and Antibiotic Resistance Patterns of Ocular Infection: Differences between External and Intraocular Diseases.眼部感染的细菌谱及抗生素耐药模式：眼外疾病与眼内疾病的差异
J Ophthalmol. 2015;2015:813979. doi: 10.1155/2015/813979. Epub 2015 Oct 21.
4
Antibiotic Resistance Among Ocular Pathogens in the United States: Five-Year Results From the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) Surveillance Study.美国眼部分离菌的抗生素耐药性：来自眼部微生物抗生素耐药性监测（ARMOR）监测研究的五年结果。
JAMA Ophthalmol. 2015 Dec;133(12):1445-54. doi: 10.1001/jamaophthalmol.2015.3888.
5
Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.成人感染性心内膜炎：诊断、抗菌治疗和并发症处理：美国心脏协会医疗保健专业人员科学声明。
Circulation. 2015 Oct 13;132(15):1435-86. doi: 10.1161/CIR.0000000000000296. Epub 2015 Sep 15.
6
Visual outcomes in treated bacterial keratitis: four years of prospective follow-up.治疗性细菌性角膜炎的视觉预后：四年前瞻性随访
Invest Ophthalmol Vis Sci. 2014 May 2;55(5):2935-40. doi: 10.1167/iovs.14-13980.
7
Emerging moxifloxacin resistance in Pseudomonas aeruginosa keratitis isolates in South India.印度南部铜绿假单胞菌角膜炎分离株中莫西沙星耐药性的出现。
Ophthalmic Epidemiol. 2013 Jun;20(3):155-8. doi: 10.3109/09286586.2013.790978. Epub 2013 May 10.
8
Emerging antibiotic resistance in ocular infections and the role of fluoroquinolones.眼感染中新兴的抗生素耐药性和氟喹诺酮类药物的作用。
J Cataract Refract Surg. 2010 Sep;36(9):1588-98. doi: 10.1016/j.jcrs.2010.06.028.
9
A multicenter comparison of polymyxin B sulfate/trimethoprim ophthalmic solution and moxifloxacin in the speed of clinical efficacy for the treatment of bacterial conjunctivitis.硫酸多粘菌素B/甲氧苄啶滴眼液与莫西沙星治疗细菌性结膜炎临床疗效速度的多中心比较
J Pediatr Ophthalmol Strabismus. 2008 Nov-Dec;45(6):340-9. doi: 10.3928/01913913-20081101-07.
10
Synergy, antagonism, and what the chequerboard puts between them.协同作用、拮抗作用，以及棋盘法介于两者之间的情况。
J Antimicrob Chemother. 2003 Jul;52(1):1. doi: 10.1093/jac/dkg301. Epub 2003 Jun 12.
Zotero 插件