Oldenburg Catherine E, Lalitha Prajna, Srinivasan Muthiah, Rajaraman Revathi, Ravindran Meenakshi, Mascarenhas Jeena, Borkar Durga S, Ray Kathryn J, Zegans Michael E, McLeod Stephen D, Porco Travis C, Lietman Thomas M, Acharya Nisha R
Francis I. Proctor Foundation, University of California, San Francisco, CA, USA.
Ophthalmic Epidemiol. 2013 Jun;20(3):155-8. doi: 10.3109/09286586.2013.790978. Epub 2013 May 10.
To describe temporal trends in Pseudomonas aeruginosa resistance to moxifloxacin in keratitis isolates from South India.
The Steroids for Corneal Ulcers Trial (SCUT) was a randomized, double-masked, placebo-controlled trial assessing outcomes in patients with culture positive bacterial corneal ulcers randomized to receive prednisolone phosphate or placebo. All patients received moxifloxacin, and susceptibility to moxifloxacin was measured at baseline using Etest. We investigated trends in moxifloxacin susceptibility of P. aeruginosa during 2007, 2008, and 2009 isolated in SCUT in South India.
There were 89 P. aeruginosa isolates during 2007, 2008, and 2009 in SCUT that were eligible for this study. There was an increase in the proportion of resistant isolates from 19% in 2007 to 52% in 2009 (p = 0.02, χ(2) test for trend). Logistic regression showed that there was a 2-fold increase in odds of resistance per 1 year increase during the study period (odds ratio 2.16, 95% confidence interval 1.09-4.26, p = 0.027).
We found a sharp increase in the proportion of isolates that were resistant to moxifloxacin from 2007 to 2009. Further work needs to be done to characterize the nature of this increase.
描述印度南部角膜溃疡分离出的铜绿假单胞菌对莫西沙星耐药性的时间趋势。
角膜溃疡类固醇试验（SCUT）是一项随机、双盲、安慰剂对照试验，评估培养阳性细菌性角膜溃疡患者被随机分配接受磷酸泼尼松龙或安慰剂后的结果。所有患者均接受莫西沙星治疗，并在基线时使用Etest测定对莫西沙星的敏感性。我们调查了2007年、2008年和2009年在印度南部SCUT中分离出的铜绿假单胞菌对莫西沙星敏感性的趋势。
2007年、2008年和2009年在SCUT中有89株铜绿假单胞菌分离株符合本研究条件。耐药分离株的比例从2007年的19%增加到2009年的52%（p = 0.02，趋势χ(2)检验）。逻辑回归显示，在研究期间，每增加1年，耐药几率增加2倍（优势比2.16，95%置信区间1.09 - 4.26，p = 0.027）。
我们发现2007年至2009年对莫西沙星耐药的分离株比例急剧增加。需要进一步开展工作以明确这种增加的性质。
