Tej Kohli Cornea Institute, Hyderabad, Telangana, India.
Center for Ocular Regeneration (CORE), L V Prasad Eye Institute, Hyderabad, Telangana, India.
Indian J Ophthalmol. 2019 Aug;67(8):1265-1277. doi: 10.4103/ijo.IJO_117_19.
Simple limbal epithelial transplantation (SLET) is an innovative limbal stem cell transplantation technique that has gained increasing popularity over the last few years. Different groups from across the world have published the clinical results of SLET in large case series with varying types and severities of limbal stem cell deficiency (LSCD). This review attempts to place all the available knowledge on SLET together in one place for the benefit of not only cornea specialists and trainees but also for residents and general ophthalmologists. It follows a balanced approach of blending evidence with experience by providing an objective analysis of published results along with helpful insights from subject experts, starting from preoperative considerations including the role of newer imaging modalities to the technical aspects of the surgery itself and the management of possible complications. Original data and novel insights on allogeneic SLET for bilateral LSCD are included in the review to address the few remaining lacunae in the existing literature on this topic. This review intends to inform, educate, and empower all aspiring and practicing SLET surgeons to optimize their clinical outcomes and to have maximal positive impact on the lives of the individuals affected by unilateral or bilateral chronic LSCD.
简单的角膜缘上皮移植术（SLET）是一种创新性的角膜缘干细胞移植技术，近年来越来越受到关注。来自世界各地的不同团队在大样本系列研究中发表了 SLET 的临床结果，涵盖了不同类型和严重程度的角膜缘干细胞缺乏症（LSCD）。本综述旨在将所有关于 SLET 的现有知识汇集在一起，不仅为角膜病专家和学员，也为住院医师和普通眼科医生提供参考。本综述通过提供对已发表结果的客观分析以及来自主题专家的有益见解，兼顾了证据和经验，从术前考虑因素（包括新型成像方式的作用）到手术本身的技术方面以及可能的并发症的管理。本综述还包括了关于异体 SLET 治疗双侧 LSCD 的原始数据和新见解，以填补该主题现有文献中的一些空白。本综述旨在为所有有抱负的和有经验的 SLET 外科医生提供信息、教育和支持，以优化他们的临床结果，并最大程度地改善受单侧或双侧慢性 LSCD 影响的个体的生活。
