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自体单纯角膜缘干细胞移植联合自体结膜移植治疗慢性单侧严重碱烧伤所致完全性角膜缘干细胞缺乏伴重度睑球粘连。

Autologous simple limbal stem cell transplantation with conjunctival autograft in chronic unilateral total LSCD with severe symblepharon due to severe alkali burn.

作者信息

Mazumdar Shefali, Chauhan Richa, Chaudhary Shelly

机构信息

Department of Ophthalmology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India

Department of Ophthalmology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.

出版信息

BMJ Case Rep. 2024 Dec 15;17(12):e262267. doi: 10.1136/bcr-2024-262267.

DOI:10.1136/bcr-2024-262267
PMID:39675809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11647074/
Abstract

This report details the case of a middle-aged man with chronic unilateral total limbal stem cell deficiency with severe symblepharon in his left eye with upper lid mechanical ptosis, restricted ocular movements and visual acuity limited to counting fingers at 2 feet. 9 months prior to his first visit, he sustained an accidental unilateral alkali injury to the left eye. He underwent autologous simple limbal epithelial transplantation combined with conjunctival autograft in the left eye. Complete ocular surface epithelialisation was achieved within 24 days post surgery. After 24 months of follow-up, the patient exhibited a stable ocular surface, normal palpebral fissure and full range of eye movements, with a best-corrected visual acuity of 6/12p in the left eye.

摘要

本报告详细介绍了一名中年男性的病例，该患者患有慢性单眼全角膜缘干细胞缺乏症，左眼伴有严重睑球粘连、上睑机械性下垂、眼球运动受限，视力仅为2英尺数指。首次就诊前9个月，他左眼意外遭受单侧碱性烧伤。他接受了左眼自体单纯角膜缘上皮移植联合自体结膜移植术。术后24天内实现了眼表上皮完全化。经过24个月的随访，患者眼表稳定，睑裂正常，眼球运动范围正常，左眼最佳矫正视力为6/12p。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/8fbc0efc6868/bcr-17-12-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/389d36b89d35/bcr-17-12-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/26d28808a3b2/bcr-17-12-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/f264187a1545/bcr-17-12-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/00bf74cca65e/bcr-17-12-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/e97e6c52e69c/bcr-17-12-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/3b3b13697be4/bcr-17-12-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/355df996893f/bcr-17-12-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/8fbc0efc6868/bcr-17-12-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/389d36b89d35/bcr-17-12-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/26d28808a3b2/bcr-17-12-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/f264187a1545/bcr-17-12-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/00bf74cca65e/bcr-17-12-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/e97e6c52e69c/bcr-17-12-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/3b3b13697be4/bcr-17-12-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/355df996893f/bcr-17-12-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c918/11647074/8fbc0efc6868/bcr-17-12-g008.jpg

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本文引用的文献

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Indian J Ophthalmol. 2023 Jul;71(7):2694-2703. doi: 10.4103/IJO.IJO_3330_22.
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The role of Tenonplasty in the management of limbal and scleral ischemia due to acute ocular chemical burns.Tenonplasty 在治疗因急性眼部化学灼伤导致的角膜缘和巩膜缺血中的作用。
Indian J Ophthalmol. 2022 Sep;70(9):3203-3212. doi: 10.4103/ijo.IJO_3148_21.
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A Review of the Diagnosis and Treatment of Limbal Stem Cell Deficiency.
角膜缘干细胞缺乏症的诊断与治疗综述
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Mini-Review: Regenerating the Corneal Epithelium With Simple Limbal Epithelial Transplantation.综述：采用简单的角膜缘上皮移植术再生角膜上皮
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