Department of Ophthalmology, Medical School of Mustafa Kemal University, Hatay, Turkey.
Department of Ophthalmology, Kars Harakani State Hospital, Kars, Turkey.
Indian J Ophthalmol. 2019 Aug;67(8):1314-1319. doi: 10.4103/ijo.IJO_220_19.
To investigate the relation between erectile dysfunction (ED) severity and pupillary functions in patients with diabetes mellitus (DM).
This prospective and observational study included 90 patients with type 2 DM and ED. Patients divided into three subgroups according to severity of ED: (i) Mild ED, (ii) Moderate ED and (iii) Severe ED groups. Thirty age-matched healthy subjects formed the control group. Main outcome measures were pupil diameter and average speed of pupil dilation. Static and dynamic pupillometry analysis was performed using the Sirius Topographer (CSO, Firenze, Italy).
Mean pupil diameter during static and dynamic pupillometry analysis were significantly greater in the control group than in the all study groups (P < 0.05). Mean pupil diameter in static pupillometry analysis was significantly different in each study group and pupil was more miotic in the Severe ED group than in the both Moderate and Mild ED groups (P < 0.05 for each). Dynamic pupillometry analysis revealed that mean pupil diameter and mean average dilation speed were significantly different in each study group throughout measurement period and the highest speed was observed in the Mild ED group and the lowest speed was observed in the severe ED group (P < 0.005 for each).
Our study results suggest that abnormal pupil functions due to diabetic autonomic neuropathy may indicate the associated ED in patients with DM.
研究糖尿病（DM）患者勃起功能障碍（ED）严重程度与瞳孔功能之间的关系。
本前瞻性观察研究纳入了 90 例 2 型 DM 合并 ED 患者。根据 ED 的严重程度将患者分为三组：（i）轻度 ED 组、（ii）中度 ED 组和（iii）重度 ED 组。30 名年龄匹配的健康受试者组成对照组。主要观察指标为瞳孔直径和瞳孔扩张平均速度。使用 Sirius topography （CSO，佛罗伦萨，意大利）进行静态和动态瞳孔测量分析。
在静态和动态瞳孔测量分析中，对照组的平均瞳孔直径明显大于所有研究组（P <0.05）。在静态瞳孔测量分析中，各研究组之间的平均瞳孔直径差异有统计学意义，重度 ED 组的瞳孔比中度和轻度 ED 组更收缩（P <0.05 ）。动态瞳孔测量分析显示，在整个测量期间，各研究组之间的平均瞳孔直径和平均平均扩张速度差异有统计学意义，轻度 ED 组的速度最快，重度 ED 组的速度最慢（P <0.005 ）。
我们的研究结果表明，糖尿病自主神经病变导致的异常瞳孔功能可能表明 DM 患者存在相关的 ED。
