Oculoplasty and Ocular Oncology Services, Centre for Sight Hospital, New Delhi, India.
Ocular Pathology Services, Centre for Sight Hospital, Hyderabad, Telangana, India.
Indian J Ophthalmol. 2019 Aug;67(8):1371-1373. doi: 10.4103/ijo.IJO_2009_18.
Adenoid cystic carcinoma (ACC) is a rarely seen malignant epithelial tumor of the eyelids. We present a rare case of primary ACC arising from the tarsal plate of the lower lid that clinically resembled a chalazion. A 66-year-old female presented with a recurring nodule in her left lower lid. She gave history of surgery for chalazion removal from the same site twice earlier. An initial diagnosis of a recurrent chalazion was made, and incision and curettage was done. Light microscopy showed a solid tumor composed predominantly of sheet-like and nested pattern of basaloid to low-columnar cells with intervening fibrovascular septa and lacking an obvious cribriform or tubular architecture. The tumor cells were positive for pan-cytokeratin and CD117 and negative for adipophilin, HMB45, and BerEP4. A diagnosis of solid variant of ACC of the eyelid was made. Wide excision was performed and eyelid defect was reconstructed.
腺样囊性癌（ACC）是一种罕见的发生于眼睑的恶性上皮性肿瘤。我们报告了 1 例罕见的原发于下睑睑板的 ACC，其临床表现类似于霰粒肿。1 例 66 岁女性因左眼下睑反复出现结节就诊。患者此前曾因同一部位的霰粒肿接受过 2 次手术切除。最初诊断为复发性霰粒肿，并进行了切开刮除术。光镜下可见一个实性肿瘤，主要由基底样到低柱状细胞的片状和巢状排列组成，其间有纤维血管间隔，缺乏明显的筛状或管状结构。肿瘤细胞广谱细胞角蛋白和 CD117 阳性，脂肪细胞分化抗原、HMB45 和 BerEP4 阴性。诊断为眼睑的实体型腺样囊性癌。进行了广泛切除，并进行了眼睑缺损重建。
