非结核分枝杆菌感染患儿辅助性 T 细胞 TH1 和 TH17 分化能力减弱。
Attenuation of Helper T Cell Capacity for TH1 and TH17 Differentiation in Children With Nontuberculous Mycobacterial Infection.
机构信息
Department of Microbial Infection & Immunity, The Ohio State University, Columbus.
Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee.
出版信息
J Infect Dis. 2019 Oct 22;220(11):1843-1847. doi: 10.1093/infdis/jiz371.
Abstract
Nontuberculous mycobacteria (NTM) infect children with increasing frequency worldwide. Using blood and lymph node tissue from children with NTM lymphadenitis, and uninfected lymph node tissue from community controls, we evaluated helper T (TH) cells in functional assays of TH1/TH17 differentiation and measured the concentration of their associated cytokines at the site of infection. Circulating TH cells from infected children were attenuated in their TH1/TH17 differentiation capacity and expressed less interferon γ and interleukin 17 after polyclonal stimulation. Similar differences were observed at the site of infection, where most cytokine concentrations were unchanged relative to controls. Our data are consistent with a model wherein TH1/TH17 differentiation is attenuated in NTM-infected children.
摘要
非结核分枝杆菌（NTM）在全球范围内感染儿童的频率不断增加。本研究使用来自 NTM 淋巴结炎患儿的血液和淋巴结组织，以及来自社区对照者的未感染淋巴结组织，评估了辅助性 T （TH）细胞在 TH1/TH17 分化的功能测定中的作用，并测量了感染部位相关细胞因子的浓度。经多克隆刺激后，来自感染患儿的循环 TH 细胞在 TH1/TH17 分化能力方面减弱，表达的干扰素γ和白细胞介素 17 减少。在感染部位也观察到类似的差异，与对照组相比，大多数细胞因子浓度没有变化。我们的数据与这样一种模型一致，即在 NTM 感染的儿童中，TH1/TH17 分化减弱。
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