Lomeo F, Khokher M A, Dandona P
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, United Kingdom.
Diabetes. 1988 Jul;37(7):912-5. doi: 10.2337/diab.37.7.912.
The effects of ethanol, acetaldehyde, and the two novel metabolites of ethanol 2,3-butanediol and 1,2-propanediol on basal and insulin-stimulated adipocyte lipogenesis and glucose oxidation in vitro were investigated. Whereas ethanol and acetaldehyde inhibited both processes at concentrations far greater than those found in alcoholic subjects, the two diols were extremely potent inhibitors of basal and insulin-stimulated adipocyte metabolism at concentrations far below those observed in alcoholic subjects. The incorporation of labeled glucose into the fatty acid moiety and glucose oxidation were inhibited at lower concentrations (0.25 microM) than those required to inhibit the incorporation of the labeled glucose into glycerol. The diols are therefore potent inhibitors of basal and insulin-stimulated adipocyte metabolism. This effect may be relevant to the pathogenesis of insulin resistance in alcoholic subjects.
研究了乙醇、乙醛以及乙醇的两种新型代谢产物2,3-丁二醇和1,2-丙二醇对体外基础状态和胰岛素刺激的脂肪细胞脂肪生成及葡萄糖氧化的影响。虽然乙醇和乙醛在浓度远高于酒精摄入者体内浓度时会抑制这两个过程，但这两种二醇在浓度远低于酒精摄入者体内观察到的浓度时，就是基础状态和胰岛素刺激的脂肪细胞代谢的极强抑制剂。与抑制标记葡萄糖掺入甘油所需的浓度相比，较低浓度（0.25微摩尔）时，标记葡萄糖掺入脂肪酸部分及葡萄糖氧化就受到了抑制。因此，二醇是基础状态和胰岛素刺激的脂肪细胞代谢的有效抑制剂。这种作用可能与酒精摄入者胰岛素抵抗的发病机制有关。
