长期乙醇喂养后大鼠脂肪组织脂肪生成和葡萄糖氧化的减少。

Decrease in lipogenesis and glucose oxidation of rat adipose tissue after chronic ethanol feeding.

作者信息

Wilson J S, Korsten M A, Colley P W, Pirola R C

出版信息

Biochem Pharmacol. 1986 Jun 15;35(12):2025-8. doi: 10.1016/0006-2952(86)90736-7.

Abstract

This investigation was performed to determine whether chronic ethanol feeding affects adipose tissue lipogenesis and glucose metabolism. Female Wistar rats were pair-fed nutritionally adequate liquid diets containing ethanol as 36% of energy or an isocaloric amount of carbohydrate for 3 weeks. Chronic ethanol feeding resulted in a depression of adipose tissue lipogenesis as assessed by labeled glucose incorporation into glyceride glycerol and glyceride fatty acids. Glucose oxidation was also impaired after chronic ethanol feeding. Such changes may contribute to the postprandial hypertriacyglyceridemia observed in alcoholics.

摘要

进行本研究以确定长期给予乙醇是否会影响脂肪组织的脂肪生成及葡萄糖代谢。将雌性Wistar大鼠成对饲养，给予营养充足的流质饮食，其中乙醇提供36%的能量，或给予等热量的碳水化合物，持续3周。通过标记葡萄糖掺入甘油酯甘油和甘油酯脂肪酸来评估，长期给予乙醇会导致脂肪组织脂肪生成减少。长期给予乙醇后，葡萄糖氧化也受到损害。这些变化可能导致酗酒者餐后出现高甘油三酯血症。