Price D E, Airey C M, Alani S M, Wales J K
Department of Medicine, General Infirmary, Leeds, United Kingdom.
Diabetes. 1988 Jul;37(7):969-73. doi: 10.2337/diab.37.7.969.
The relationships between nerve polyol levels and both nerve conduction velocity (NCV) and resistance to ischemic conduction block (RICB) in streptozocin-induced diabetic rats were examined in two studies. In the first study, sciatic NCV and RICB of the tail nerve, assessed by measuring the time to disappearance of the nerve action potential after the tail was rendered ischemic, were measured in nondiabetic rats, untreated diabetic rats, and diabetic rats given Statil, an aldose reductase inhibitor (ARI). Sciatic NCV was lower in the untreated diabetic animals than in control animals (P less than .05), and RICB of the tail nerve was greater (P less than .001). Treatment with the ARI completely prevented the slowing of NCV but had no significant effect on the increase in RICB. In the second study, similar groups of rats were treated with either ARI, insulin, or myo-inositol. Sciatic NCV was lower in the untreated diabetic rats than in the nondiabetic rats (P less than .001). In diabetic rats treated with the ARI and in those treated with insulin, NCV was greater than in the untreated diabetic rats (P less than .05 and P less than .001, respectively) and was not significantly different from the nondiabetic rats. NCV in the myo-inositol-treated rats was not significantly different from that in the untreated diabetic rats. RICB was assessed by measuring the decline in sciatic nerve action potential amplitude at minute intervals after death.(ABSTRACT TRUNCATED AT 250 WORDS)
在两项研究中，对链脲佐菌素诱导的糖尿病大鼠神经多元醇水平与神经传导速度（NCV）和缺血性传导阻滞抵抗性（RICB）之间的关系进行了研究。在第一项研究中，通过测量尾巴缺血后神经动作电位消失的时间来评估非糖尿病大鼠、未经治疗的糖尿病大鼠以及给予醛糖还原酶抑制剂（ARI）Statil的糖尿病大鼠的坐骨神经NCV和尾神经RICB。未经治疗的糖尿病动物的坐骨神经NCV低于对照动物（P<0.05），尾神经的RICB更高（P<0.001）。用ARI治疗可完全防止NCV减慢，但对RICB增加无显著影响。在第二项研究中，类似的大鼠组用ARI、胰岛素或肌醇进行治疗。未经治疗的糖尿病大鼠的坐骨神经NCV低于非糖尿病大鼠（P<0.001）。用ARI治疗的糖尿病大鼠和用胰岛素治疗的糖尿病大鼠的NCV高于未经治疗的糖尿病大鼠（分别为P<0.05和P<0.001），且与非糖尿病大鼠无显著差异。用肌醇治疗的大鼠的NCV与未经治疗的糖尿病大鼠无显著差异。通过在死亡后每隔一分钟测量坐骨神经动作电位幅度的下降来评估RICB。（摘要截短至250字）
