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Leflunomide: an unlikely trigger and mechanistically a beneficial drug for alopecia areata.

作者信息

Sardana Kabir, Gupta Aastha, Gupta Pulin Kumar

机构信息

Department of Dermatology, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Road, New Delhi, 110001, India.

Department of Medicine, Post Graduate Institute of Medical Education and Research, Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Road, New Delhi, 110001, India.

出版信息

Clin Rheumatol. 2019 Oct;38(10):2957-2958. doi: 10.1007/s10067-019-04669-0. Epub 2019 Jul 23.

DOI:10.1007/s10067-019-04669-0
PMID:31332691
Abstract
摘要

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1
Leflunomide: an unlikely trigger and mechanistically a beneficial drug for alopecia areata.来氟米特：斑秃不太可能的诱因，但从机制上来说是一种对斑秃有益的药物。
Clin Rheumatol. 2019 Oct;38(10):2957-2958. doi: 10.1007/s10067-019-04669-0. Epub 2019 Jul 23.
2
[Alopecia areata secondary to the use of leflunomide in patients with rheumatoid arthritis: a case report and literature review].[类风湿关节炎患者使用来氟米特继发斑秃：一例报告及文献复习]
Medwave. 2015 Dec 30;15(11):e6350. doi: 10.5867/medwave.2015.11.6350.
3
Response: Leflunomide: potential treatment and cause of alopecia areata.
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4
Alopecia areata in a patient with rheumatoid arthritis treated with leflunomide.
J Rheumatol. 2002 Aug;29(8):1806-7.
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Alopecia areata during treatment of psoriasis with adalimumab and leflunomide: a case and review of the literature.阿达木单抗和来氟米特治疗银屑病致斑秃 1 例并文献复习
Skin Pharmacol Physiol. 2012;25(2):107-10. doi: 10.1159/000335264. Epub 2012 Jan 31.
6
Recalcitrant alopecia areata responsive to leflunomide and anthralin-Potentially undiscovered JAK/STAT inhibitors?对来氟米特和蒽林有反应的顽固性斑秃——潜在的未被发现的JAK/STAT抑制剂？
Pediatr Dermatol. 2018 Nov;35(6):856-858. doi: 10.1111/pde.13688. Epub 2018 Oct 15.
7
The Changing Landscape of Alopecia Areata: An Introduction.斑秃的变化态势：引言
Adv Ther. 2017 Jul;34(7):1584-1585. doi: 10.1007/s12325-017-0544-5.
8
Current and future treatments of alopecia areata and trichotillomania in children.儿童斑秃和拔毛癖的当前及未来治疗方法。
Expert Opin Pharmacother. 2016 Sep;17(13):1767-73. doi: 10.1080/14656566.2016.1217990. Epub 2016 Aug 9.
9
Major causes of alopecia with suggestions for history taking, workup, and therapy.
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Leflunomide: a manageable safety profile.来氟米特：安全性可控。
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本文引用的文献

1
Reversible alopecia areata: a little known side effect of leflunomide.可逆性斑秃：来氟米特一个鲜为人知的副作用。
Clin Rheumatol. 2019 Jul;38(7):2015-2016. doi: 10.1007/s10067-019-04577-3. Epub 2019 May 1.
2
Drug-induced alopecia after dupilumab therapy.度普利尤单抗治疗后药物性脱发
JAAD Case Rep. 2018 Dec 6;5(1):54-56. doi: 10.1016/j.jdcr.2018.10.010. eCollection 2019 Jan.
3
Recalcitrant alopecia areata responsive to leflunomide and anthralin-Potentially undiscovered JAK/STAT inhibitors?对来氟米特和蒽林有反应的顽固性斑秃——潜在的未被发现的JAK/STAT抑制剂？
Pediatr Dermatol. 2018 Nov;35(6):856-858. doi: 10.1111/pde.13688. Epub 2018 Oct 15.
4
Nivolumab-induced alopecia areata: A reversible factor of good prognosis?纳武单抗诱导的斑秃：预后良好的可逆因素？
JAAD Case Rep. 2018 Sep 14;4(8):761-765. doi: 10.1016/j.jdcr.2018.05.022. eCollection 2018 Sep.
5
Leflunomide and teriflunomide: altering the metabolism of pyrimidines for the treatment of autoimmune diseases.来氟米特和特立氟胺：改变嘧啶代谢以治疗自身免疫性疾病。
Expert Rev Clin Pharmacol. 2015 May;8(3):315-20. doi: 10.1586/17512433.2015.1019343. Epub 2015 Feb 24.
6
Efficacy and safety of methotrexate in alopecia areata.甲氨蝶呤治疗斑秃的疗效与安全性。
An Bras Dermatol. 2014 Sep-Oct;89(5):729-34. doi: 10.1590/abd1806-4841.20142869.
7
Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.斑秃由细胞毒性 T 淋巴细胞驱动，并可被 JAK 抑制逆转。
Nat Med. 2014 Sep;20(9):1043-9. doi: 10.1038/nm.3645. Epub 2014 Aug 17.
8
Alopecia areata occurring during anti-TNF therapy: a national multicenter prospective study.抗TNF治疗期间发生的斑秃：一项全国多中心前瞻性研究。
J Am Acad Dermatol. 2014 Jun;70(6):1146-9. doi: 10.1016/j.jaad.2014.03.005.
9
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis.来氟米特和甲氨蝶呤对类风湿关节炎细胞因子产生的不同影响。
Ann Rheum Dis. 2004 Sep;63(9):1056-61. doi: 10.1136/ard.2003.014738. Epub 2004 Apr 28.
10
Third International Research Workshop on Alopecia Areata.
J Invest Dermatol. 1999 May;112(5):822-4. doi: 10.1046/j.1523-1747.1999.00571.x.