Gözü Pirinccioglu Ayfer, Alyan Ömer, Akin Alper, Kizil Göksel, Işik Fatma Birgul
Department of Pediatrics, School of Medicine, Dicle University, Diyarbakır, Turkey.
Department of Chemistry, Science Faculty, Dicle University, Diyarbakır, Turkey.
Pediatr Int. 2019 Oct;61(10):962-966. doi: 10.1111/ped.13983.
The aim of this study was to investigate of the role of oxidative stress (OS) in acute rheumatic fever (ARF) and its relationship with the progress of the disease.
Thirty patients with ARF and 31 age-sex-matched healthy children were enrolled in this study. Serum malondialdehyde (MDA), protein carbonyl (PCO), high-sensitivity C-reactive protein (hs-CRP), cytokines (tumor necrosis factor-α and interleukin-6) and total antioxidant capacity (TAC) were measured. The diagnosis of ARF was based on the Jones criteria.
Patients with ARF had significantly higher serum MDA, PCO, hs-CRP and cytokine levels and lower TAC than healthy controls. On Pearson's correlation analysis we found that oxidative stress markers were positively correlated with hs-CRP and cytokines, while TAC was negatively correlated with MDA, PCO, hs-CRP and cytokines. The number of valves involved as well as the level of mitral valve involvement was also significantly related to the oxidative stress parameters and TAC. All oxidative stress parameters decreased significantly with anti-inflammatory therapy while TAC increased.
Malondialdehyde and PCO, as biomarkers, as well as hs-CRP together with the other available diagnostic tools, can be used in the evaluation of patients with ARF.
本研究旨在探讨氧化应激（OS）在急性风湿热（ARF）中的作用及其与疾病进展的关系。
本研究纳入了30例ARF患者和31例年龄、性别匹配的健康儿童。检测血清丙二醛（MDA）、蛋白质羰基（PCO）、高敏C反应蛋白（hs-CRP）、细胞因子（肿瘤坏死因子-α和白细胞介素-6）以及总抗氧化能力（TAC）。ARF的诊断基于琼斯标准。
ARF患者的血清MDA、PCO、hs-CRP和细胞因子水平显著高于健康对照组，而TAC则较低。经Pearson相关性分析，我们发现氧化应激标志物与hs-CRP和细胞因子呈正相关，而TAC与MDA、PCO、hs-CRP和细胞因子呈负相关。受累瓣膜的数量以及二尖瓣受累程度也与氧化应激参数和TAC显著相关。抗炎治疗后，所有氧化应激参数均显著降低，而TAC升高。
丙二醛和PCO作为生物标志物，与hs-CRP以及其他现有的诊断工具一起，可用于评估ARF患者。
