Pirinccioglu Ayfer Gözü, Alyan Omer, Kizil Göksel, Kangin Murat, Beyazit Nurcan
Department of Pediatrics, University of Dicle, Diyarbakir, Turkey.
Pediatr Int. 2012 Feb;54(1):94-8. doi: 10.1111/j.1442-200X.2011.03478.x. Epub 2011 Nov 29.
A significant cause of death and chronic illness in childhood is caused by cardiovascular diseases, including congenital heart disease (CHD). This study aims to investigate the oxidative stress status and to establish its association with CHD in children.
The study involves measurements of malondialdehyde (MDA), protein carbonyl (PCO), total anti-oxidant capacity, high-sensitive C-reactive protein (hs-CRP), fibrinogen and cytokine (interleukin [IL-6] and tumor necrosis factor-α) levels in 43 children with CHD and 30 healthy age-matched children.
MDA, PCO, hs-CRP, fibrinogen, IL-6 and tumor necrosis factor-α were significantly elevated while total anti-oxidant capacity was significantly declined in patients compared with the controls. MDA was positively correlated with PCO, hs-CRP, Qp/Qs and systolic pulmonary artery pressure. PCO was positively correlated with hs-CRP, fibrinogen, IL-6 and systolic pulmonary artery pressure.
Oxidative stress and its association with other markers in children with CHD was established. To the best of our knowledge, this is the first time that PCO has been used as a biomarker in CHD and it may be employed as a new diagnostic biomarker in CHD and in the assessment of its severity.
心血管疾病，包括先天性心脏病（CHD），是儿童死亡和慢性病的一个重要原因。本研究旨在调查儿童的氧化应激状态，并确定其与CHD的关联。
该研究对43例CHD患儿和30例年龄匹配的健康儿童进行了丙二醛（MDA）、蛋白质羰基（PCO）、总抗氧化能力、高敏C反应蛋白（hs-CRP）、纤维蛋白原和细胞因子（白细胞介素[IL-6]和肿瘤坏死因子-α）水平的测量。
与对照组相比，患者的MDA、PCO、hs-CRP、纤维蛋白原、IL-6和肿瘤坏死因子-α显著升高，而总抗氧化能力显著下降。MDA与PCO、hs-CRP、Qp/Qs和收缩期肺动脉压呈正相关。PCO与hs-CRP、纤维蛋白原、IL-6和收缩期肺动脉压呈正相关。
确定了CHD患儿的氧化应激及其与其他标志物的关联。据我们所知，这是首次将PCO用作CHD的生物标志物，它可能被用作CHD的一种新的诊断生物标志物及其严重程度的评估指标。
