Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610 Mo i Rana, Norway
Department of Internal Medicine, Semey Medical University, Semey, Kazakhstan
Curr Med Chem. 2020;27(40):6837-6848. doi: 10.2174/0929867326666190722153305.
The concentrations of metals in the environment are still not within the recommended limits as set by the regulatory authorities in various countries because of human activities. They can enter the food chain and bioaccumulate in soft and hard tissues/organs, often with a long half-life of the metal in the body. Metal exposure has a negative impact on bone health and may result in osteoporosis and increased fracture risk depending on concentration and duration of metal exposure and metal species. Bones are a long-term repository for lead and some other metals, and may approximately contain 90% of the total body burden in birds and mammals. The present review focuses on the most common metals found in contaminated areas (mercury, cadmium, lead, nickel, chromium, iron, and aluminum) and their effects on bone tissue, considering the possibility of the long-term bone accumulation, and also some differences that might exist between different age groups in the whole population.
由于人类活动，环境中的金属浓度仍未达到各国监管机构规定的建议限值。它们可以进入食物链，并在软组织和硬组织/器官中生物累积，金属在体内的半衰期通常很长。金属暴露对骨骼健康有负面影响，根据金属暴露的浓度和时间以及金属种类的不同，可能导致骨质疏松症和骨折风险增加。骨骼是铅和其他一些金属的长期储存库，在鸟类和哺乳动物中，骨骼大约含有 90%的体内总负荷。本综述重点关注污染地区常见的金属（汞、镉、铅、镍、铬、铁和铝）及其对骨骼组织的影响，同时考虑到长期骨骼积累的可能性，以及整个人群中不同年龄组之间可能存在的一些差异。
