Department of Public Health, University of Naples Federico II, Naples, Italy.
Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.
Curr Pharm Des. 2019;25(22):2421-2427. doi: 10.2174/1381612825666190722095401.
Vitamin D is involved in the physiological functions of several tissues, however, its deficiency may contribute to the development of various disorders. Recent research has been focusing on the role of vitamin D in the pathogenesis of endometriosis based on the evidence of the presence of vitamin D receptor and the enzymes required for vitamin D synthesis in the ectopic endometrium. Endometriosis, defined as the presence of endometrial glands and stroma in ectopic locations, is considered an estrogen-dependent disease and Vitamin D seems to have a role in modulation of the inflammatory state and proliferation of endometriotic cells.
This study aimed to review the available literature regarding the relationship between vitamin D and endometriosis as well as the effects of vitamin D supplementation.
A search on PubMed database has been performed.
The relationship between endometriosis and Vitamin D has been analyzed through the evaluation of vitamin D serum level, the polymorphism of vitamin D receptor and the role of vitamin D-binding protein in patient with endometriosis. The possible role of Vitamin D in the endometriosis therapy has also been investigated, in particular, the effect of vitamin D on pain relief, on endometriotic lesion in vitro and in rat models and in addition to a future target immunotherapy.
Although promising, the data analyzed are not sufficient to evidence a cause-effect relationship between VD status and endometriosis, therefore further studies are needed in order to better clarify the association between vitamin D and endometriosis, especially in the context of the possibility of new treatment options.
维生素 D 参与了多种组织的生理功能，但其缺乏可能导致各种疾病的发生。最近的研究集中在维生素 D 在子宫内膜异位症发病机制中的作用，这是基于在外位子宫内膜中存在维生素 D 受体和合成维生素 D 的酶的证据。子宫内膜异位症是指子宫内膜腺体和基质出现在异位部位，被认为是一种雌激素依赖性疾病，而维生素 D 似乎在调节子宫内膜异位症细胞的炎症状态和增殖方面发挥作用。
本研究旨在回顾关于维生素 D 与子宫内膜异位症之间关系以及维生素 D 补充的相关文献。
在 PubMed 数据库上进行了检索。
通过评估子宫内膜异位症患者的维生素 D 血清水平、维生素 D 受体的多态性以及维生素 D 结合蛋白的作用，分析了子宫内膜异位症与维生素 D 之间的关系。还研究了维生素 D 在子宫内膜异位症治疗中的可能作用，特别是维生素 D 对疼痛缓解、体外和大鼠模型中的子宫内膜异位病灶的影响，以及未来的免疫治疗靶点。
尽管有希望，但分析的数据不足以证明维生素 D 状态与子宫内膜异位症之间存在因果关系，因此需要进一步的研究，以更好地阐明维生素 D 与子宫内膜异位症之间的关联，特别是在考虑新的治疗选择的可能性的情况下。
