Aix-Marseille-Univ., Institut de Recherche pour le Développement, Microbes, Evolution, Phylogénie et Infection, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.
IHU Méditerranée Infection, Marseille, France.
Am J Trop Med Hyg. 2019 Sep;101(3):491-493. doi: 10.4269/ajtmh.19-0137.
Buruli ulcer is an infectious disease provoking chronic, disabling skin ulcers in mammals and humans. Buruli ulcer is caused by , an environmental mycobacterium synthesizing a toxin called mycolactone responsible for the pathogenicity. The reservoirs and the modes of transmission of remain elusive, limiting the prophylaxis capabilities in rural areas in endemic countries. In Australia, several studies have demonstrated the probable role of possums as reservoirs. In Côte d'Ivoire, some studies have speculated on the potential role of grasscutters in the transmission cycle of . In this study, we detected -specific sequences in rectal contents and spleens collected in wild grasscutters hunted in Buruli ulcer-endemic area in Côte d'Ivoire, but not in farmed negative control animals and in domesticated animals, namely, pigs, goats, cattle, and dogs, living in close contact with the local population. Some grasscutters exhibited the same sequence pattern in the feces and spleen. These observations confirm the asymptomatic gut carriage of in this mammal species. Moreover, these observations suggest the dissemination of from the gut to the spleen in grasscutters. These observations suggest that, in some mammals, is not only an inoculated pathogen but also a translocating invasive pathogen.
布鲁里溃疡是一种传染病，可导致哺乳动物和人类出现慢性、致残性皮肤溃疡。布鲁里溃疡由 引起，这是一种环境分枝杆菌，可合成一种名为 mycolactone 的毒素，该毒素是导致疾病的原因。的宿主和传播方式仍不清楚，这限制了在流行国家农村地区的预防能力。在澳大利亚，多项研究已经证明，负鼠可能是宿主之一。在科特迪瓦，一些研究推测，草食动物可能在 的传播循环中发挥作用。在这项研究中，我们在科特迪瓦布鲁里溃疡流行地区猎捕的野生草食动物的直肠内容物和脾脏中检测到了 - 特异性序列，但在农场阴性对照动物和与当地居民密切接触的家养动物（猪、山羊、牛和狗）中没有检测到。一些草食动物的粪便和脾脏中出现了相同的序列模式。这些观察结果证实了该微生物在这种哺乳动物中无症状的肠道携带。此外，这些观察结果表明，在草食动物中，从肠道传播到脾脏。这些观察结果表明，在某些哺乳动物中， 不仅是一种接种病原体，也是一种易位侵袭性病原体。
