Antimycoplasmal activities of the pseudomonic acids and structure-activity relationships of monic acid A derivatives.
作者信息
Banks R M, Donald A C, Hannan P C, O'Hanlon P J, Rogers N H
机构信息
Beecham Pharmaceuticals Research Division, Tadworth, Surrey, UK.
出版信息
J Antibiot (Tokyo). 1988 May;41(5):609-13. doi: 10.7164/antibiotics.41.609.
PMID:3133344
Abstract
The antimycoplasmal activities of the pseudomonic acids isolated from Pseudomonas fluorescens NCIB 10586 are reported. Structure-activity relationships of a variety of ester, amide and thiol ester derivatives of the nucleus, monic acid A, are described. Enhanced antimycoplasmal activity is reported for a number of monic acid A esters and the most potent derivative, m-nitrobenzyl monate A, is a 100-fold more active against Mycoplasma hyopneumoniae than pseudomonic acid A.
摘要
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