假单胞菌酸的化学。第16部分。莫尼酸的芳基和杂芳基酮衍生物。
Chemistry of pseudomonic acid. Part 16. Aryl and heteroaryl ketone derivatives of monic acid.
作者信息
Abson A, Broom N J, Coates P A, Elder J S, Forrest A K, Hannan P C, Hicks A J, O'Hanlon P J, Masson N D, Pearson N D, Pons J E, Wilson J M
机构信息
SmithKline Beecham Pharmaceuticals, Brockham Park, Betchworth, Surrey, UK.
出版信息
J Antibiot (Tokyo). 1996 Apr;49(4):390-4. doi: 10.7164/antibiotics.49.390.
PMID:8642004
Abstract
The synthesis, antibacterial activities, murine pharmacokinetic and infection model data for a range of aryl and heteroaryl ketone derivatives of monic acid (2a) are reported. The best results were found for the 3-furyl and 2-methoxy thiazol-5-yl analogues.
摘要
报道了一系列莫尼酸（2a）的芳基和杂芳基酮衍生物的合成、抗菌活性、小鼠药代动力学及感染模型数据。3-呋喃基和2-甲氧基噻唑-5-基类似物的结果最佳。
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